ID   PROF_SUBDO              Reviewed;         140 AA.
AC   Q9U0E6;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Profilin;
OS   Suberites domuncula (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha; Suberitida;
OC   Suberitidae; Suberites.
OX   NCBI_TaxID=55567;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10619600; DOI=10.1089/104454999314746;
RA   Mueller W.E.G., Perovic S., Wilkesman J., Kruse M., Mueller I.M., Batel R.;
RT   "Increased gene expression of a cytokine-related molecule and profilin
RT   after activation of Suberites domuncula cells with xenogeneic sponge
RT   molecule(s).";
RL   DNA Cell Biol. 18:885-893(1999).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; Y18900; CAB65408.1; -; mRNA.
DR   AlphaFoldDB; Q9U0E6; -.
DR   SMR; Q9U0E6; -.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0044087; P:regulation of cellular component biogenesis; IEA:UniProt.
DR   GO; GO:0051128; P:regulation of cellular component organization; IEA:UniProt.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   2: Evidence at transcript level;
FT   CHAIN           1..140
FT                   /note="Profilin"
FT                   /id="PRO_0000199603"
SQ   SEQUENCE   140 AA;  14712 MW;  C9EE3FBC49EE34F2 CRC64;
     MSWDSYLDNL VAQSKDASGT AHVDRCCIIG LDGGAAWTTA GHACALKLQG QEGPNIAKCF
     KSKDFTAFMS GGVRAEGEKY QFLREEEGKT VLAKKKGNGA ITLQASKTAI VLGHCPEGGQ
     QGNTNKAVGV IADYLESLGM