ID   PROF_TRYBB              Reviewed;         150 AA.
AC   Q26734;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Profilin;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=427;
RX   PubMed=9099881; DOI=10.1016/s0378-1119(96)00749-4;
RA   Wilson W., Seebeck T.;
RT   "Identification of a profilin homologue in Trypanosoma brucei by
RT   complementation screening.";
RL   Gene 187:201-209(1997).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; Z72391; CAA96531.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q26734; -.
DR   SMR; Q26734; -.
DR   GO; GO:0097014; C:ciliary plasm; IDA:GeneDB.
DR   GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0031981; C:nuclear lumen; IDA:GeneDB.
DR   GO; GO:0003779; F:actin binding; ISM:GeneDB.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Cytoskeleton.
FT   CHAIN           1..150
FT                   /note="Profilin"
FT                   /id="PRO_0000199605"
SQ   SEQUENCE   150 AA;  16122 MW;  CAC9EE9CD049F5C1 CRC64;
     MSWQSYVDDS LVGSGFMHSA AIVGLADGSY WAYGGTYVPQ PEEVTHILKC LENFSLVQSS
     GVTICGVKFF GLQSGSEGQM KYIFFKKGAA GGCIYTSKQT AIIAVYGNPG DASALQQDLQ
     KTEATYVAVN PADCNTTVKR IAEYLISLDY