ID   PROF_VACCA              Reviewed;         128 AA.
AC   O57243;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   07-APR-2021, entry version 60.
DE   RecName: Full=Profilin;
GN   OrderedLocusNames=MVA154R, ACAM3000_MVA_154;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: More likely to influence phosphoinositide metabolism than
CC       actin assembly. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; U94848; AAB96534.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10552.1; -; Genomic_DNA.
DR   PIR; T37427; T37427.
DR   SMR; O57243; -.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   Pfam; PF00235; Profilin; 1.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   3: Inferred from homology;
KW   Actin-binding.
FT   CHAIN           1..128
FT                   /note="Profilin"
FT                   /id="PRO_0000199680"
SQ   SEQUENCE   128 AA;  14543 MW;  CD685D436B6F0038 CRC64;
     MAEWHKIIED ISKNNKFEDA AIVDYKTTKN VLAAIPNRTF AKINPLITNR NILKPLIGQK
     YCIVYTNSLM DENTYAMELL TGYAPVSPIV IARTHTALIF LMGKPTTSRR DVYRTCRDHA
     TRVRATGN