ID   PROF_VACCC              Reviewed;         133 AA.
AC   P68695; P20844;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   29-SEP-2021, entry version 58.
DE   RecName: Full=Profilin;
GN   ORFNames=A42R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Participates in either intracellular transport of viral
CC       proteins or intercellular spread of the virus. Cellular profilins
CC       modulate actin filament dynamics (polymerization and depolymerization)
CC       via direct binding to actin through an actin-binding domain as well as
CC       by modulation of other actin-binding proteins. In contrast to cellular
CC       homologs, the poxvirus profilins seem to bind actin only weakly (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host TPM1. Interacts with protein A25 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Note=Localizes to inclusion
CC       bodies formed by viral A25/ATI protein in the cytoplasm of the host
CC       cell.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48173.1; -; Genomic_DNA.
DR   PIR; B40897; FAVZVR.
DR   SMR; P68695; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0039680; P:actin-dependent intracellular transport of virus towards nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   Pfam; PF00235; Profilin; 1.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Actin-dependent inwards viral transport;
KW   Cytoplasmic inwards viral transport; Host cytoplasm;
KW   Host-virus interaction; Reference proteome; Virus entry into host cell.
FT   CHAIN           1..133
FT                   /note="Profilin"
FT                   /id="PRO_0000199681"
SQ   SEQUENCE   133 AA;  15052 MW;  C76E5D9FA31E8669 CRC64;
     MAEWHKIIED ISKNNKFEDA AIVDYKTTKN VLAAIPNRTF AKINPGEIIP LITNRNILKP
     LIGQKYCIVY TNSLMDENTY AMELLTGYAP VSPIVIARTH TALIFLMGKP TTSRRDVYRT
     CRDHATRVRA TGN