ID   PROF_VAR67              Reviewed;         133 AA.
AC   P0DSW5; P33828; Q76PV8;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   12-AUG-2020, entry version 5.
DE   RecName: Full=Profilin;
GN   ORFNames=A42R, A45R, A47R, A50R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Participates in either intracellular transport of viral
CC       proteins or intercellular spread of the virus. Cellular profilins
CC       modulate actin filament dynamics (polymerization and depolymerization)
CC       via direct binding to actin through an actin-binding domain as well as
CC       by modulation of other actin-binding proteins. In contrast to cellular
CC       homologs, the poxvirus profilins seem to bind actin only weakly (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host TPM1. Interacts with protein A25 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Note=Localizes to inclusion
CC       bodies formed by viral A25/ATI protein in the cytoplasm of the host
CC       cell.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; X69198; CAA49094.1; -; Genomic_DNA.
DR   PIR; C36853; C36853.
DR   RefSeq; NP_042197.1; NC_001611.1.
DR   SMR; P0DSW5; -.
DR   GeneID; 1486528; -.
DR   KEGG; vg:1486528; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0039680; P:actin-dependent intracellular transport of virus towards nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   Pfam; PF00235; Profilin; 1.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Actin-dependent inwards viral transport;
KW   Cytoplasmic inwards viral transport; Host cytoplasm;
KW   Host-virus interaction; Reference proteome; Virus entry into host cell.
FT   CHAIN           1..133
FT                   /note="Profilin"
FT                   /id="PRO_0000199684"
SQ   SEQUENCE   133 AA;  14989 MW;  7FF189DD419B29D2 CRC64;
     MAEWHKIIED ISKNNNFEDA AIVDYKTTKN VLAAIPNRTF AKINPGEVIP LITNHNILKP
     LIGQKFCIVY TNSLMDENTY AMELLTGYAP VSPIVIARTH TALIFLMGKP TTSRRDVYRT
     CRDHATRVRA TGN