ID   PROF_VARV               Reviewed;         133 AA.
AC   P0DSW6; P33828; Q76PV8;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=Profilin;
GN   ORFNames=A42R, A45R, A47R, A50R;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Harvey;
RX   PubMed=1331292; DOI=10.1099/0022-1317-73-11-2887;
RA   Aguado B., Selmes I.P., Smith G.L.;
RT   "Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and
RT   comparison with vaccinia virus.";
RL   J. Gen. Virol. 73:2887-2902(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Garcia-1966;
RX   PubMed=10639322; DOI=10.1006/viro.1999.0086;
RA   Shchelkunov S.N., Totmenin A.V., Loparev V.N., Safronov P.F., Gutorov V.V.,
RA   Chizhikov V.E., Knight J.C., Parsons J.M., Massung R.F., Esposito J.J.;
RT   "Alastrim smallpox variola minor virus genome DNA sequences.";
RL   Virology 266:361-386(2000).
CC   -!- FUNCTION: Participates in either intracellular transport of viral
CC       proteins or intercellular spread of the virus. Cellular profilins
CC       modulate actin filament dynamics (polymerization and depolymerization)
CC       via direct binding to actin through an actin-binding domain as well as
CC       by modulation of other actin-binding proteins. In contrast to cellular
CC       homologs, the poxvirus profilins seem to bind actin only weakly (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host TPM1. Interacts with protein A25 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Note=Localizes to inclusion
CC       bodies formed by viral A25/ATI protein in the cytoplasm of the host
CC       cell.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; L22579; AAA60897.1; -; Genomic_DNA.
DR   EMBL; Y16780; CAB54753.1; -; Genomic_DNA.
DR   PIR; C36853; C36853.
DR   RefSeq; NP_042197.1; NC_001611.1.
DR   SMR; P0DSW6; -.
DR   GeneID; 1486528; -.
DR   KEGG; vg:1486528; -.
DR   Proteomes; UP000111493; Genome.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0039680; P:actin-dependent intracellular transport of virus towards nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   Pfam; PF00235; Profilin; 1.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Actin-dependent inwards viral transport;
KW   Cytoplasmic inwards viral transport; Host cytoplasm;
KW   Host-virus interaction; Virus entry into host cell.
FT   CHAIN           1..133
FT                   /note="Profilin"
FT                   /id="PRO_0000448117"
SQ   SEQUENCE   133 AA;  14989 MW;  7FF189DD419B29D2 CRC64;
     MAEWHKIIED ISKNNNFEDA AIVDYKTTKN VLAAIPNRTF AKINPGEVIP LITNHNILKP
     LIGQKFCIVY TNSLMDENTY AMELLTGYAP VSPIVIARTH TALIFLMGKP TTSRRDVYRT
     CRDHATRVRA TGN