ID   PROH1_APIME             Reviewed;          91 AA.
AC   P85798;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Prohormone-1;
DE   Contains:
DE     RecName: Full=Brain peptide LRNQLDIGDLQ;
DE   Contains:
DE     RecName: Full=Brain peptide LRNQLDIGDL;
DE   Contains:
DE     RecName: Full=Brain peptide SYWKQCAFNAVSCF-amide;
DE   Flags: Precursor;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DH4;
RG   Honey bee genome project;
RA   Zhang L., Deng J., Wu Y.-Q., Kovar C., Aqrawi P., Bandaranaike D.,
RA   Blankenburg K., Chen D., Denson S., Dinh H., Firestine M., Gross S.,
RA   Han Y., Hernandez B., Holder M., Jackson L., Javaid M., Jing C., Jones J.,
RA   Joshi V., Kamau G., Korchina V., Lee S., Lorensuhewa L., Mata R.,
RA   Mathew T., Mims S., Ngo R., Nguyen L., Okwuonu G., Ongeri F., Osuji N.,
RA   Pham C., Puazo M., Qu C., Quiroz J., Raj R., Rio Deiros D., Santibanez J.,
RA   Scheel M., Scherer S., Vee V., Wang M., Xin Y., Richards S., Reid J.G.,
RA   Newsham I., Worley K.C., Muzny D.M., Gibbs R.;
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 62-72 AND 76-89, MASS SPECTROMETRY, DISULFIDE BOND, AND
RP   AMIDATION AT PHE-89.
RC   TISSUE=Brain {ECO:0000269|PubMed:17068263};
RX   PubMed=17068263; DOI=10.1126/science.1124128;
RA   Hummon A.B., Richmond T.A., Verleyen P., Baggerman G., Huybrechts J.,
RA   Ewing M.A., Vierstraete E., Rodriguez-Zas S.L., Schoofs L., Robinson G.E.,
RA   Sweedler J.V.;
RT   "From the genome to the proteome: uncovering peptides in the Apis brain.";
RL   Science 314:647-649(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: [Brain peptide LRNQLDIGDLQ]: Mass=1283.68;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC   -!- MASS SPECTROMETRY: [Brain peptide LRNQLDIGDL]: Mass=1155.62;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC   -!- MASS SPECTROMETRY: [Brain peptide SYWKQCAFNAVSCF-amide]: Mass=1649.71;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
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DR   EMBL; AADG06001907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006570428.1; XM_006570365.2.
DR   RefSeq; XP_016770380.1; XM_016914891.1.
DR   AlphaFoldDB; P85798; -.
DR   STRING; 7460.GB43201-PA; -.
DR   PaxDb; P85798; -.
DR   EnsemblMetazoa; XM_006570365; XP_006570428; LOC725616.
DR   EnsemblMetazoa; XM_016914891; XP_016770380; LOC725616.
DR   GeneID; 725616; -.
DR   KEGG; ame:725616; -.
DR   eggNOG; ENOG502S8U2; Eukaryota.
DR   HOGENOM; CLU_160227_0_0_1; -.
DR   InParanoid; P85798; -.
DR   OMA; VISKMMS; -.
DR   PhylomeDB; P85798; -.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..59
FT                   /evidence="ECO:0000269|PubMed:17068263"
FT                   /id="PRO_0000341465"
FT   PEPTIDE         62..72
FT                   /note="Brain peptide LRNQLDIGDLQ"
FT                   /id="PRO_0000341466"
FT   PEPTIDE         62..71
FT                   /note="Brain peptide LRNQLDIGDL"
FT                   /id="PRO_0000341467"
FT   PROPEP          73
FT                   /evidence="ECO:0000269|PubMed:17068263"
FT                   /id="PRO_0000341468"
FT   PEPTIDE         76..89
FT                   /note="Brain peptide SYWKQCAFNAVSCF-amide"
FT                   /id="PRO_0000341469"
FT   MOD_RES         89
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:17068263"
FT   DISULFID        81..88
FT                   /evidence="ECO:0000269|PubMed:17068263"
SQ   SEQUENCE   91 AA;  10354 MW;  E50D844F404EB80B CRC64;
     MSSLRIAMFL LVVLMVLIDC STAIPAADKE RLLNEVDLVD DDGSIETALI NYLFTKQIVK
     RLRNQLDIGD LQRKRSYWKQ CAFNAVSCFG K