ID   PROH3_APIME             Reviewed;         314 AA.
AC   P85828;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Prohormone-3;
DE   Contains:
DE     RecName: Full=Brain peptide ITGQGNRIF;
DE   Flags: Precursor;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DH4;
RG   Honey bee genome project;
RA   Zhang L., Deng J., Wu Y.-Q., Kovar C., Aqrawi P., Bandaranaike D.,
RA   Blankenburg K., Chen D., Denson S., Dinh H., Firestine M., Gross S.,
RA   Han Y., Hernandez B., Holder M., Jackson L., Javaid M., Jing C., Jones J.,
RA   Joshi V., Kamau G., Korchina V., Lee S., Lorensuhewa L., Mata R.,
RA   Mathew T., Mims S., Ngo R., Nguyen L., Okwuonu G., Ongeri F., Osuji N.,
RA   Pham C., Puazo M., Qu C., Quiroz J., Raj R., Rio Deiros D., Santibanez J.,
RA   Scheel M., Scherer S., Vee V., Wang M., Xin Y., Richards S., Reid J.G.,
RA   Newsham I., Worley K.C., Muzny D.M., Gibbs R.;
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 297-305, AND MASS SPECTROMETRY.
RC   TISSUE=Brain {ECO:0000269|PubMed:17068263};
RX   PubMed=17068263; DOI=10.1126/science.1124128;
RA   Hummon A.B., Richmond T.A., Verleyen P., Baggerman G., Huybrechts J.,
RA   Ewing M.A., Vierstraete E., Rodriguez-Zas S.L., Schoofs L., Robinson G.E.,
RA   Sweedler J.V.;
RT   "From the genome to the proteome: uncovering peptides in the Apis brain.";
RL   Science 314:647-649(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: [Brain peptide ITGQGNRIF]: Mass=1004.54;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC   -!- MASS SPECTROMETRY: [Brain peptide ITGQGNRIF]: Mass=1004.54;
CC       Method=MALDI; Evidence={ECO:0000269|PubMed:17068263};
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DR   EMBL; AADG06002762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P85828; -.
DR   STRING; 7460.GB50651-PA; -.
DR   PaxDb; P85828; -.
DR   eggNOG; ENOG502RYQ1; Eukaryota.
DR   OrthoDB; 1139517at2759; -.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..314
FT                   /note="Prohormone-3"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000339283"
FT   PEPTIDE         297..305
FT                   /note="Brain peptide ITGQGNRIF"
FT                   /id="PRO_0000339284"
FT   TRANSMEM        90..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   314 AA;  35035 MW;  A4040373F95F93D9 CRC64;
     MGRVLLSASS LLLHIQVFTR RLGNEYIEQD RPPCGTSGHP GSIRPTEMKT MTFGLNDEER
     AKHPRESEVL NENGAARFQQ RYTHMGQKMY TCVALTVVAL VSTMHFGVEA WGGLFNRFSP
     EMLSNLGYGS HGDHISKSGL YQRPLSTSYG YSYDSLEEVI PCYERKCTLN EHCCPGSICM
     NVDGDVGHCV FELGQKQGEL CRNDNDCETG LMCAEVAGSE TRSCQVPITS NKLYNEECNV
     SGECDISRGL CCQLQRRHRQ TPRKVCSYFK DPLVCIGPVA TDQIKSIVQY TSGEKRITGQ
     GNRIFKRSLK APFA