PROH4_APIME
ID PROH4_APIME Reviewed; 202 AA.
AC P85831;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Prohormone-4;
DE Contains:
DE RecName: Full=Brain peptide IDLSRFYGHFNT;
DE Contains:
DE RecName: Full=Brain peptide IDLSRFYGHFN;
DE Contains:
DE RecName: Full=Brain peptide IDLSRFYGHF;
DE Contains:
DE RecName: Full=Brain peptide DLSRFYGHFNT;
DE Contains:
DE RecName: Full=Brain peptide DLSRFYGHFN;
DE Contains:
DE RecName: Full=Brain peptide DLSRFYGHF;
DE Flags: Precursor;
OS Apis mellifera (Honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC Apis.
OX NCBI_TaxID=7460;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH4;
RG Honey bee genome project;
RA Zhang L., Deng J., Wu Y.-Q., Kovar C., Aqrawi P., Bandaranaike D.,
RA Blankenburg K., Chen D., Denson S., Dinh H., Firestine M., Gross S.,
RA Han Y., Hernandez B., Holder M., Jackson L., Javaid M., Jing C., Jones J.,
RA Joshi V., Kamau G., Korchina V., Lee S., Lorensuhewa L., Mata R.,
RA Mathew T., Mims S., Ngo R., Nguyen L., Okwuonu G., Ongeri F., Osuji N.,
RA Pham C., Puazo M., Qu C., Quiroz J., Raj R., Rio Deiros D., Santibanez J.,
RA Scheel M., Scherer S., Vee V., Wang M., Xin Y., Richards S., Reid J.G.,
RA Newsham I., Worley K.C., Muzny D.M., Gibbs R.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 29-40, AND MASS SPECTROMETRY.
RC TISSUE=Brain {ECO:0000269|PubMed:17068263};
RX PubMed=17068263; DOI=10.1126/science.1124128;
RA Hummon A.B., Richmond T.A., Verleyen P., Baggerman G., Huybrechts J.,
RA Ewing M.A., Vierstraete E., Rodriguez-Zas S.L., Schoofs L., Robinson G.E.,
RA Sweedler J.V.;
RT "From the genome to the proteome: uncovering peptides in the Apis brain.";
RL Science 314:647-649(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- MASS SPECTROMETRY: [Brain peptide IDLSRFYGHFNT]: Mass=1468.71;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Brain peptide IDLSRFYGHFNT]: Mass=1468.71;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Brain peptide IDLSRFYGHFN]: Mass=1367.66;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Brain peptide IDLSRFYGHFN]: Mass=1367.66;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Brain peptide IDLSRFYGHF]: Mass=1253.62;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Brain peptide IDLSRFYGHF]: Mass=1253.62;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Brain peptide DLSRFYGHFNT]: Mass=1355.63;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Brain peptide DLSRFYGHFN]: Mass=1254.58;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Brain peptide DLSRFYGHFN]: Mass=1254.58;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:17068263};
CC -!- MASS SPECTROMETRY: [Brain peptide DLSRFYGHF]: Mass=1140.54;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:17068263};
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DR EMBL; AADG06001864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_392764.1; XM_392764.6.
DR AlphaFoldDB; P85831; -.
DR STRING; 7460.GB45263-PA; -.
DR PaxDb; P85831; -.
DR EnsemblMetazoa; XM_392764; XP_392764; LOC409241.
DR GeneID; 409241; -.
DR KEGG; ame:409241; -.
DR eggNOG; ENOG502QT8V; Eukaryota.
DR HOGENOM; CLU_095820_0_0_1; -.
DR InParanoid; P85831; -.
DR OMA; GICISIQ; -.
DR OrthoDB; 1489754at2759; -.
DR PhylomeDB; P85831; -.
DR Proteomes; UP000005203; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00112; LDLa; 1.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF57424; SSF57424; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..202
FT /note="Prohormone-4"
FT /evidence="ECO:0000255"
FT /id="PRO_0000339285"
FT PEPTIDE 29..40
FT /note="Brain peptide IDLSRFYGHFNT"
FT /id="PRO_0000339286"
FT PEPTIDE 29..39
FT /note="Brain peptide IDLSRFYGHFN"
FT /id="PRO_0000339287"
FT PEPTIDE 29..38
FT /note="Brain peptide IDLSRFYGHF"
FT /id="PRO_0000339288"
FT PEPTIDE 30..40
FT /note="Brain peptide DLSRFYGHFNT"
FT /id="PRO_0000339289"
FT PEPTIDE 30..39
FT /note="Brain peptide DLSRFYGHFN"
FT /id="PRO_0000339290"
FT PEPTIDE 30..38
FT /note="Brain peptide DLSRFYGHF"
FT /id="PRO_0000339291"
FT DOMAIN 46..86
FT /note="LDL-receptor class A"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 47..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 55..74
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 68..85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 202 AA; 22081 MW; 95A0C4E6BFEC7A7B CRC64;
MVQRLCTSVA ALSLALSACV FFPRAVMAID LSRFYGHFNT KRSGDACRPY EPFKCPGDDT
CISIQYLCDG APDCQDGYDE DSRLCTAAKR PPVEETASFL QSLLASHGPN YLEKLFGTKA
RDTLKPLGGV NTVAIALSES QTIEDFGAAL HLLRTDLEHL RSVFMAVENG DLGMLKSIGI
KDSELGDVKF FLEKLVKTGF LD
