PROK1_MOUSE
ID PROK1_MOUSE Reviewed; 105 AA.
AC Q14A28; Q0P609; Q8K457;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Prokineticin-1 {ECO:0000312|EMBL:AAI17009.1};
DE AltName: Full=Endocrine-gland-derived vascular endothelial growth factor {ECO:0000250|UniProtKB:P58294};
DE Short=EG-VEGF {ECO:0000250|UniProtKB:P58294};
DE Flags: Precursor;
GN Name=Prok1 {ECO:0000312|MGI:MGI:2180370};
GN Synonyms=Pk1 {ECO:0000312|EMBL:AAM49573.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Kidney {ECO:0000269|PubMed:12746324};
RX PubMed=12746324; DOI=10.1210/en.2002-0146;
RA LeCouter J., Lin R., Frantz G., Zhang Z., Hillan K., Ferrara N.;
RT "Mouse endocrine gland-derived vascular endothelial growth factor: a
RT distinct expression pattern from its human ortholog suggests different
RT roles as a regulator of organ-specific angiogenesis.";
RL Endocrinology 144:2606-2616(2003).
RN [2] {ECO:0000305, ECO:0000312|EMBL:EDL01898.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAI17007.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAH42707.1};
RC TISSUE=Kidney {ECO:0000312|EMBL:AAH42707.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305, ECO:0000312|EMBL:EDL01898.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 25-105 (ISOFORMS 1/2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAM49573.1};
RA Cheng M.Y., Bullock C.M., Li C., Lee A.G., Bermak J.C., Belluzzi J.,
RA Weaver D.R., Leslie F.M., Zhou Q.Y.;
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17324478; DOI=10.1016/j.bbamcr.2007.01.013;
RA Ngan E.S.W., Lee K.Y., Sit F.Y.L., Poon H.C., Chan J.K.Y., Sham M.H.,
RA Lui V.C.H., Tam P.K.H.;
RT "Prokineticin-1 modulates proliferation and differentiation of enteric
RT neural crest cells.";
RL Biochim. Biophys. Acta 1773:536-545(2007).
RN [6] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17531315; DOI=10.1016/j.placenta.2007.03.008;
RA Hoffmann P., Feige J.-J., Alfaidy N.;
RT "Placental expression of EG-VEGF and its receptors PKR1 (prokineticin
RT receptor-1) and PKR2 throughout mouse gestation.";
RL Placenta 28:1049-1058(2007).
CC -!- FUNCTION: Potently contracts gastrointestinal (GI) smooth muscle.
CC Induces proliferation, migration and fenestration (the formation of
CC membrane discontinuities) in capillary endothelial cells. Induces
CC proliferation and differentiation, but not migration, of enteric neural
CC crest cells. Directly influences neuroblastoma progression by promoting
CC the proliferation and migration of neuroblastoma cells. Positively
CC regulates PTGS2 expression and prostaglandin synthesis. May play a role
CC in placentation. May play a role in normal and pathological testis
CC angiogenesis. {ECO:0000250|UniProtKB:P58294,
CC ECO:0000269|PubMed:12746324, ECO:0000269|PubMed:17324478,
CC ECO:0000269|PubMed:17531315}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P58294}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:12746324, ECO:0000269|PubMed:15489334};
CC IsoId=Q14A28-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:15489334};
CC IsoId=Q14A28-2; Sequence=VSP_053117;
CC -!- TISSUE SPECIFICITY: Highly expressed in liver and ovary and weakly
CC expressed in testis and placenta. Expressed in mucosa and mesenchyme of
CC embryonic gut during enteric nervous system development (at protein
CC level). Predominantly expressed in kidney and liver. Also expressed in
CC lung, ovary, placenta and testis. In fetal liver, is restricted to and
CC highly expressed in hepatocytes. In adult kidney, expression is
CC restricted to the endothelial tubule cells. In placenta, expressed
CC throughout gestation. {ECO:0000269|PubMed:12746324,
CC ECO:0000269|PubMed:17324478, ECO:0000269|PubMed:17531315}.
CC -!- DEVELOPMENTAL STAGE: In placenta, at 7.5 dpc highly expressed in
CC ectoplacental cone, endoderm and in giant cells, and at 9.5 dpc
CC restricted mainly to the labyrinth layer (at protein level). In
CC placenta, most highly expressed during early gestation (between 9.5 and
CC 10.5 dpc). {ECO:0000269|PubMed:17531315}.
CC -!- SIMILARITY: Belongs to the AVIT (prokineticin) family. {ECO:0000255}.
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DR EMBL; CH466607; EDL01898.1; -; Genomic_DNA.
DR EMBL; BC042707; AAH42707.1; -; mRNA.
DR EMBL; BC117006; AAI17007.1; -; mRNA.
DR EMBL; BC117008; AAI17009.1; -; mRNA.
DR EMBL; AF487281; AAM49573.1; -; mRNA.
DR CCDS; CCDS38589.1; -. [Q14A28-1]
DR CCDS; CCDS89674.1; -. [Q14A28-2]
DR RefSeq; NP_001037847.1; NM_001044382.1. [Q14A28-1]
DR RefSeq; XP_017175073.1; XM_017319584.1.
DR AlphaFoldDB; Q14A28; -.
DR SMR; Q14A28; -.
DR STRING; 10090.ENSMUSP00000060617; -.
DR PhosphoSitePlus; Q14A28; -.
DR PaxDb; Q14A28; -.
DR PRIDE; Q14A28; -.
DR Antibodypedia; 20098; 318 antibodies from 30 providers.
DR Ensembl; ENSMUST00000049852; ENSMUSP00000060617; ENSMUSG00000070368. [Q14A28-1]
DR Ensembl; ENSMUST00000197758; ENSMUSP00000143197; ENSMUSG00000070368. [Q14A28-2]
DR GeneID; 246691; -.
DR KEGG; mmu:246691; -.
DR UCSC; uc008qwv.1; mouse. [Q14A28-1]
DR CTD; 84432; -.
DR MGI; MGI:2180370; Prok1.
DR VEuPathDB; HostDB:ENSMUSG00000070368; -.
DR eggNOG; ENOG502S1PW; Eukaryota.
DR GeneTree; ENSGT00940000161331; -.
DR InParanoid; Q14A28; -.
DR OMA; GACERDI; -.
DR OrthoDB; 1517288at2759; -.
DR PhylomeDB; Q14A28; -.
DR TreeFam; TF332732; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 246691; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q14A28; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q14A28; protein.
DR Bgee; ENSMUSG00000070368; Expressed in right kidney and 11 other tissues.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0001664; F:G protein-coupled receptor binding; TAS:DFLAT.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0008283; P:cell population proliferation; IDA:MGI.
DR GO; GO:0007623; P:circadian rhythm; TAS:MGI.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI.
DR GO; GO:1905564; P:positive regulation of vascular endothelial cell proliferation; IDA:MGI.
DR GO; GO:0045765; P:regulation of angiogenesis; IDA:MGI.
DR GO; GO:0101023; P:vascular endothelial cell proliferation; IDA:MGI.
DR InterPro; IPR009523; Prokineticin.
DR InterPro; IPR023569; Prokineticin_domain.
DR PANTHER; PTHR18821; PTHR18821; 1.
DR Pfam; PF06607; Prokineticin; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Angiogenesis; Disulfide bond; Growth factor; Mitogen;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..105
FT /note="Prokineticin-1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000377457"
FT DISULFID 26..38
FT /evidence="ECO:0000250|UniProtKB:P25687"
FT DISULFID 32..50
FT /evidence="ECO:0000250|UniProtKB:P25687"
FT DISULFID 37..78
FT /evidence="ECO:0000250|UniProtKB:P25687"
FT DISULFID 60..86
FT /evidence="ECO:0000250|UniProtKB:P25687"
FT DISULFID 80..96
FT /evidence="ECO:0000250|UniProtKB:P25687"
FT VAR_SEQ 1..24
FT /note="MRGAVHIFIMLLLATASDCAVITG -> MKAVVKTK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_053117"
SQ SEQUENCE 105 AA; 11678 MW; 0C75428C310B528F CRC64;
MRGAVHIFIM LLLATASDCA VITGACERDI QCGAGTCCAI SLWLRGLRLC TPLGREGEEC
HPGSHKIPFL RKRQHHTCPC SPSLLCSRFP DGRYRCFRDL KNANF
