ID   PROK1_PELSA             Reviewed;          24 AA.
AC   P84909;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Prokineticin 1-like protein;
DE   Flags: Fragment;
OS   Pelophylax saharicus (Sahara frog) (Rana saharica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=70019;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Skin secretion;
RX   PubMed=16269346; DOI=10.1016/j.peptides.2005.03.008;
RA   Marenah L., Flatt P.R., Orr D.F., Shaw C., Abdel-Wahab Y.H.A.;
RT   "Isolation and structural characterization of novel Rugosin A-like
RT   insulinotropic peptide from the skin secretions of Rana saharica frog.";
RL   Peptides 26:2117-2123(2005).
CC   -!- FUNCTION: Stimulates insulin secretion by BRIN-BD11 cells in vitro.
CC       {ECO:0000269|PubMed:16269346}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16269346}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:16269346}.
CC   -!- MASS SPECTROMETRY: Mass=2930.8; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:16269346};
CC   -!- SIMILARITY: Belongs to the AVIT (prokineticin) family. {ECO:0000305}.
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DR   AlphaFoldDB; P84909; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0032024; P:positive regulation of insulin secretion; IDA:UniProtKB.
DR   InterPro; IPR023569; Prokineticin_domain.
DR   Pfam; PF06607; Prokineticin; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing; Disulfide bond;
KW   Secreted.
FT   CHAIN           1..>24
FT                   /note="Prokineticin 1-like protein"
FT                   /id="PRO_0000248508"
FT   DISULFID        7..19
FT                   /evidence="ECO:0000250|UniProtKB:P25687"
FT   DISULFID        13..?
FT                   /evidence="ECO:0000250|UniProtKB:P25687"
FT   DISULFID        18..?
FT                   /evidence="ECO:0000250|UniProtKB:P25687"
FT   NON_TER         24
FT                   /evidence="ECO:0000303|PubMed:16269346"
SQ   SEQUENCE   24 AA;  2327 MW;  0C348F8FC6E61785 CRC64;
     AVITGACERD VQCGGGTCCA VSLI