ID   PROK1_RAT               Reviewed;         105 AA.
AC   Q8R414;
DT   19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Prokineticin-1;
DE   AltName: Full=Endocrine-gland-derived vascular endothelial growth factor;
DE            Short=EG-VEGF;
DE   Flags: Precursor;
GN   Name=Prok1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=12054613; DOI=10.1016/s0006-291x(02)00239-5;
RA   Masuda Y., Takatsu Y., Terao Y., Kumano S., Ishibashi Y., Suenaga M.,
RA   Abe M., Fukusumi S., Watanabe T., Shintani Y., Yamada T., Hinuma S.,
RA   Inatomi N., Ohtaki T., Onda H., Fujino M.;
RT   "Isolation and identification of EG-VEGF/prokineticins as cognate ligands
RT   for two orphan G-protein-coupled receptors.";
RL   Biochem. Biophys. Res. Commun. 293:396-402(2002).
CC   -!- FUNCTION: Potently contracts gastrointestinal (GI) smooth muscle.
CC       Induces proliferation, migration and fenestration (the formation of
CC       membrane discontinuities) in capillary endothelial cells derived from
CC       endocrine glands. Has little or no effect on a variety of other
CC       endothelial and non-endothelial cell types. Induces proliferation and
CC       differentiation, but not migration, of enteric neural crest cells.
CC       Directly influences neuroblastoma progression by promoting the
CC       proliferation and migration of neuroblastoma cells. Positively
CC       regulates PTGS2 expression and prostaglandin synthesis. May play a role
CC       in placentation. May play a role in normal and pathological testis
CC       angiogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AVIT (prokineticin) family. {ECO:0000305}.
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DR   EMBL; AY089983; AAM09104.1; -; mRNA.
DR   RefSeq; NP_620206.1; NM_138851.1.
DR   RefSeq; XP_017446090.1; XM_017590601.1.
DR   AlphaFoldDB; Q8R414; -.
DR   SMR; Q8R414; -.
DR   STRING; 10116.ENSRNOP00000024519; -.
DR   PaxDb; Q8R414; -.
DR   Ensembl; ENSRNOT00000024519; ENSRNOP00000024519; ENSRNOG00000018201.
DR   GeneID; 192205; -.
DR   KEGG; rno:192205; -.
DR   UCSC; RGD:620898; rat.
DR   CTD; 84432; -.
DR   RGD; 620898; Prok1.
DR   eggNOG; ENOG502S1PW; Eukaryota.
DR   GeneTree; ENSGT00940000161331; -.
DR   HOGENOM; CLU_143202_2_0_1; -.
DR   InParanoid; Q8R414; -.
DR   OMA; GACERDI; -.
DR   OrthoDB; 1517288at2759; -.
DR   PhylomeDB; Q8R414; -.
DR   TreeFam; TF332732; -.
DR   Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR   Reactome; R-RNO-416476; G alpha (q) signalling events.
DR   PRO; PR:Q8R414; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000018201; Expressed in kidney and 3 other tissues.
DR   Genevisible; Q8R414; RN.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0008283; P:cell population proliferation; TAS:RGD.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR   GO; GO:1905564; P:positive regulation of vascular endothelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0045765; P:regulation of angiogenesis; ISO:RGD.
DR   GO; GO:0101023; P:vascular endothelial cell proliferation; IEA:Ensembl.
DR   InterPro; IPR009523; Prokineticin.
DR   InterPro; IPR023569; Prokineticin_domain.
DR   PANTHER; PTHR18821; PTHR18821; 1.
DR   Pfam; PF06607; Prokineticin; 1.
PE   3: Inferred from homology;
KW   Angiogenesis; Disulfide bond; Growth factor; Mitogen; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..105
FT                   /note="Prokineticin-1"
FT                   /id="PRO_0000025808"
FT   DISULFID        26..38
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..50
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..78
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..86
FT                   /evidence="ECO:0000250"
FT   DISULFID        80..96
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   105 AA;  11643 MW;  8DF0C42122B1C5B6 CRC64;
     MRGAVQVFIM LLLATVSDCA VITGACERDV QCGAGTCCAI SLWLRGLRLC TPLGREGEEC
     HPGSHKIPFF RKRQHHTCPC SPSLLCSRFP DGRYRCSQDL KNVNF