PROK2_BOVIN
ID PROK2_BOVIN Reviewed; 128 AA.
AC Q863H5; Q863H4;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Prokineticin-2;
DE Short=PK2;
DE Flags: Precursor;
GN Name=PROK2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=12728244; DOI=10.1038/sj.embor.embor830;
RA Kaser A., Winklmayr M., Lepperdinger G., Kreil G.;
RT "The AVIT protein family. Secreted cysteine-rich vertebrate proteins with
RT diverse functions.";
RL EMBO Rep. 4:469-473(2003).
CC -!- FUNCTION: May function as an output molecule from the suprachiasmatic
CC nucleus (SCN) that transmits behavioral circadian rhythm. May also
CC function locally within the SCN to synchronize output. Potently
CC contracts gastrointestinal (GI) smooth muscle (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q863H5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q863H5-2; Sequence=VSP_021965;
CC -!- SIMILARITY: Belongs to the AVIT (prokineticin) family. {ECO:0000305}.
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DR EMBL; AY192557; AAP31906.1; -; mRNA.
DR EMBL; AY192558; AAP31907.1; -; mRNA.
DR RefSeq; NP_955516.1; NM_199445.1. [Q863H5-1]
DR AlphaFoldDB; Q863H5; -.
DR SMR; Q863H5; -.
DR STRING; 9913.ENSBTAP00000025742; -.
DR PaxDb; Q863H5; -.
DR GeneID; 387602; -.
DR KEGG; bta:387602; -.
DR CTD; 60675; -.
DR eggNOG; ENOG502SU1D; Eukaryota.
DR HOGENOM; CLU_143202_1_0_1; -.
DR InParanoid; Q863H5; -.
DR OrthoDB; 1517288at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR GO; GO:0001935; P:endothelial cell proliferation; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; ISS:UniProtKB.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR InterPro; IPR009523; Prokineticin.
DR InterPro; IPR023569; Prokineticin_domain.
DR PANTHER; PTHR18821; PTHR18821; 1.
DR Pfam; PF06607; Prokineticin; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Biological rhythms; Disulfide bond; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..128
FT /note="Prokineticin-2"
FT /id="PRO_0000268188"
FT REGION 71..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..95
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 34..46
FT /evidence="ECO:0000250"
FT DISULFID 40..58
FT /evidence="ECO:0000250"
FT DISULFID 45..106
FT /evidence="ECO:0000250"
FT DISULFID 68..114
FT /evidence="ECO:0000250"
FT DISULFID 108..124
FT /evidence="ECO:0000250"
FT VAR_SEQ 75..94
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12728244"
FT /id="VSP_021965"
SQ SEQUENCE 128 AA; 14290 MW; C22CDBDBE40483EC CRC64;
MRSSRCARLL LLLLLPPLLL TPPAGDAAVI TGACDRDPQC GGGMCCAVSL WVKSIRICTP
MGKVGDSCHP MTRKNHFGNG RQERRKRKRR RKKKVPFLGR RMHHTCPCLP GLACSRTSFN
RYTCLAQK
