PROML_DROME
ID PROML_DROME Reviewed; 1013 AA.
AC P82295; A4V1D5; A8WHI2; Q95RK1; Q9VZV0;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Prominin-like protein;
GN Name=prominin-like; ORFNames=CG7740;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Corbeil D., Roper K., Huttner W.B.;
RT "Sequence analysis of a Drosophila ortholog of mouse prominin and human
RT prominin(mouse)-like 1.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 482-1013.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 978-1013.
RC STRAIN=Berkeley; TISSUE=Ovary;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-99 AND ASN-576, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-linked
RT cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the prominin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL28872.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAO39605.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=AAO39605.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AF127935; AAD22487.2; -; mRNA.
DR EMBL; AF197345; AAF07212.1; -; mRNA.
DR EMBL; AE014296; AAF47716.2; -; Genomic_DNA.
DR EMBL; AE014296; AAN11530.1; -; Genomic_DNA.
DR EMBL; AE014296; AAN11531.1; -; Genomic_DNA.
DR EMBL; BT031128; ABX00750.1; -; mRNA.
DR EMBL; AY061324; AAL28872.1; ALT_INIT; mRNA.
DR EMBL; BT003602; AAO39605.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001261351.1; NM_001274422.1.
DR RefSeq; NP_647770.1; NM_139513.3.
DR RefSeq; NP_728809.1; NM_167986.1.
DR RefSeq; NP_728810.1; NM_167987.4.
DR AlphaFoldDB; P82295; -.
DR SMR; P82295; -.
DR BioGRID; 63870; 4.
DR DIP; DIP-18139N; -.
DR IntAct; P82295; 11.
DR STRING; 7227.FBpp0072980; -.
DR GlyGen; P82295; 7 sites.
DR iPTMnet; P82295; -.
DR PaxDb; P82295; -.
DR PRIDE; P82295; -.
DR DNASU; 38372; -.
DR EnsemblMetazoa; FBtr0073118; FBpp0072980; FBgn0026189.
DR EnsemblMetazoa; FBtr0073119; FBpp0072981; FBgn0026189.
DR EnsemblMetazoa; FBtr0073120; FBpp0072982; FBgn0026189.
DR EnsemblMetazoa; FBtr0333895; FBpp0306027; FBgn0026189.
DR GeneID; 38372; -.
DR KEGG; dme:Dmel_CG7740; -.
DR CTD; 38372; -.
DR FlyBase; FBgn0026189; prominin-like.
DR VEuPathDB; VectorBase:FBgn0026189; -.
DR eggNOG; KOG4331; Eukaryota.
DR GeneTree; ENSGT00530000063586; -.
DR InParanoid; P82295; -.
DR PhylomeDB; P82295; -.
DR SignaLink; P82295; -.
DR BioGRID-ORCS; 38372; 1 hit in 3 CRISPR screens.
DR ChiTaRS; prominin-like; fly.
DR GenomeRNAi; 38372; -.
DR PRO; PR:P82295; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0026189; Expressed in central nervous system and 28 other tissues.
DR ExpressionAtlas; P82295; baseline and differential.
DR Genevisible; P82295; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008795; Prominin.
DR PANTHER; PTHR22730; PTHR22730; 1.
DR Pfam; PF05478; Prominin; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1013
FT /note="Prominin-like protein"
FT /id="PRO_0000218281"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 489..509
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 535..555
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 852..872
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 918..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..938
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1001
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 576
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973"
FT CARBOHYD 618
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 803
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 824
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 949
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1013 AA; 115106 MW; 88B69163AF5FAFB3 CRC64;
MGEVAATVEP LAAVKSKSMR SRKRRQRRRR QIAYLAICGL SVAIFGFALA TLIRPTTAQA
DADPGSWRKG YVGHGTTHEQ LGQPHWPPVQ YTVYRPTTNY TKAPPPPTSA MNPIFNFTHF
LYDKVLYRDE PIPEGYIVVK NSDTLSLGPK VEENDWRDLL AHYWMVLIWV VILVVLIIVI
PFIAVCYCCF CCCRRCRQGC PPCTSKQDAQ RRFCCGICLL ILIIGLIFGI IIAFVTNKMI
DSGFAETSET MKRGSEDTCT YLKDVADHVH HLMMYNYEEM ETHVLDQLTH AHRHIFLDLS
DTSESNSLAE MERVLENMPE ALELMRQVEK MEKDLRFYGS QLRDGVRGIK RDVNFAVANL
CQLQMCQKFL ISSNIEHIDS SQCLHFDNLP NTKEFVEGME NIVASEYYAI PQRGLSRLKK
VSDKVKTQLS FVVPPMMRDL TKGRTIFREH ATNVRNIVEG VLSDIHIKTL HSTKSFEDVY
ERFGHDRNVV SLIVCLLILL VLFILIFALL CGCFGRRRTG YGDECCSKST GATCLLLAIL
LIFCVFSFIA LVGLFYFMLG MVTYQGACAP LRDQENNTLF RQLDASIDLN HYLPPSESNK
EVVQPLKMSS AIKACHANQT IFDMMRQHNI YDINDLTRIK VMSHSQENTD SIKVFDEDLS
TVVLLTKEER DELKTAGESK LAKYHSSLYM PSLCTQFTPM NLNALSEQLY KLSNDLEYPA
YGWAKVSFWN EGLNTKAFYR NFVPKLTSLV EKMKANLKKI DELISYENHD FTNTIKILTA
TAINSEQFIQ TRGKDYINAL GGNLTNSIDQ MIDDYIDMII KEANESVGHC APLSYIYYRG
VDLICHRIVD PINGFWVGIL LCALLFLPIL FVAHRLMCLY KKIYPYLATV GAAGVVEGGS
DYLYDAYSER DREHVPLANV PKKRRKAYER RREQQDYFED ASPSVSRGNR SGGDRGGGGG
DGAPGSSSMR YNDMAPTHWD HEPPRYHNPP AAPPSSEYER PPPYYYPGAS EQD
