ID   PROP1_BOVIN             Reviewed;         226 AA.
AC   Q8MJI9; Q8MJI8; Q8MJJ0;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Homeobox protein prophet of Pit-1;
DE            Short=PROP-1;
DE   AltName: Full=Pituitary-specific homeodomain factor;
GN   Name=PROP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANT HIS-173.
RX   PubMed=12095694; DOI=10.1016/s0378-1119(02)00599-1;
RA   Showalter A.D., Smith T.P.L., Bennett G.L., Sloop K.W., Whitsett J.A.,
RA   Rhodes S.J.;
RT   "Differential conservation of transcriptional domains of mammalian Prophet
RT   of Pit-1 proteins revealed by structural studies of the bovine gene and
RT   comparative functional analysis of the protein.";
RL   Gene 291:211-221(2002).
CC   -!- FUNCTION: Possibly involved in the ontogenesis of pituitary
CC       gonadotropes, as well as somatotropes, lactotropes and caudomedial
CC       thyrotropes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Exclusively expressed in the developing pituitary
CC       gland.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; AF453510; AAM22639.1; -; mRNA.
DR   EMBL; AF453511; AAM22640.1; -; mRNA.
DR   EMBL; AF453512; AAM22641.1; -; Genomic_DNA.
DR   RefSeq; NP_777103.1; NM_174678.3.
DR   RefSeq; XP_015327641.1; XM_015472155.1.
DR   AlphaFoldDB; Q8MJI9; -.
DR   SMR; Q8MJI9; -.
DR   STRING; 9913.ENSBTAP00000009680; -.
DR   PaxDb; Q8MJI9; -.
DR   GeneID; 282563; -.
DR   KEGG; bta:282563; -.
DR   CTD; 5626; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   HOGENOM; CLU_044912_1_0_1; -.
DR   InParanoid; Q8MJI9; -.
DR   OrthoDB; 1351285at2759; -.
DR   TreeFam; TF315976; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0021983; P:pituitary gland development; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR042412; PROP1.
DR   PANTHER; PTHR47409; PTHR47409; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..226
FT                   /note="Homeobox protein prophet of Pit-1"
FT                   /id="PRO_0000049267"
FT   DNA_BIND        69..128
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          44..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..219
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         173
FT                   /note="R -> H"
FT                   /evidence="ECO:0000269|PubMed:12095694"
SQ   SEQUENCE   226 AA;  25400 MW;  BA162A0F77D864B6 CRC64;
     MDTEGSSEQG KQTKEQVCSS LWPEGYPAAE TVTSSVDMNT QPYRNLSGVR VGRPKLSLQG
     VQRGRPHSRR RHRTTFSPAQ LEQLESAFGR NQYPDIWARE SLAQDTGLSE ARIQVWFQNR
     RAKQRKQERS LLQPLAHLSP ATFSGFLPEP PSCPYSYPTP PPPMTCFPHP YNRALPSQPS
     TGSSFARPYQ SEDWYPNLHP TPAGHLACPP PPPMLPLSLE PPKSWN