ID   PROP1_CANLF             Reviewed;         226 AA.
AC   Q9TTD8;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Homeobox protein prophet of Pit-1;
DE            Short=PROP-1;
DE   AltName: Full=Pituitary-specific homeodomain factor;
GN   Name=PROP1;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10773688; DOI=10.1159/000015507;
RA   Lantinga-van Leeuwen I.S., Kooistra H.S., Mol J.A., Renier C., Breen M.,
RA   van Oost B.A.;
RT   "Cloning, characterization, and physical mapping of the canine Prop-1 gene
RT   (PROP1): exclusion as a candidate for combined pituitary hormone deficiency
RT   in German shepherd dogs.";
RL   Cytogenet. Cell Genet. 88:140-144(2000).
CC   -!- FUNCTION: Possibly involved in the ontogenesis of pituitary
CC       gonadotropes, as well as somatotropes, lactotropes and caudomedial
CC       thyrotropes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; AF126157; AAF23266.1; -; Genomic_DNA.
DR   RefSeq; NP_001018643.1; NM_001020807.1.
DR   AlphaFoldDB; Q9TTD8; -.
DR   SMR; Q9TTD8; -.
DR   STRING; 9612.ENSCAFP00000000382; -.
DR   PaxDb; Q9TTD8; -.
DR   Ensembl; ENSCAFT00030009836; ENSCAFP00030008606; ENSCAFG00030005366.
DR   Ensembl; ENSCAFT00040018326; ENSCAFP00040015910; ENSCAFG00040009885.
DR   Ensembl; ENSCAFT00845016377; ENSCAFP00845012740; ENSCAFG00845009295.
DR   GeneID; 474647; -.
DR   KEGG; cfa:474647; -.
DR   CTD; 5626; -.
DR   VEuPathDB; HostDB:ENSCAFG00845009295; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000162292; -.
DR   HOGENOM; CLU_044912_1_0_1; -.
DR   InParanoid; Q9TTD8; -.
DR   OMA; EPPKSWN; -.
DR   OrthoDB; 1351285at2759; -.
DR   TreeFam; TF315976; -.
DR   Proteomes; UP000002254; Chromosome 11.
DR   Bgee; ENSCAFG00000000268; Expressed in pituitary gland.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0021983; P:pituitary gland development; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR042412; PROP1.
DR   PANTHER; PTHR47409; PTHR47409; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..226
FT                   /note="Homeobox protein prophet of Pit-1"
FT                   /id="PRO_0000049268"
FT   DNA_BIND        69..128
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..218
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  25205 MW;  650DD02B49F405B7 CRC64;
     MEAEGRSERG KQKKGRLCGS LWPDSYPAAG TLTSTVDVSP QPSKNLSGVG VRRPRLSPQG
     GQRGRLHSRR RHRTTFNPGQ LEQLETAFGR NQYPDIWARE GLARDTGLSE ARIQVWFQNR
     RAKQRKQERS LLQPLAHLSP ATFSGFLPES PACPYSYPTP PPPMTCFPHP YNHALPSQPS
     TGGSFARPHQ SEDWYPTLHP PPTGHLPCPP PPTMLPLSLE PPKSWN