ID   PROP1_GORGO             Reviewed;         225 AA.
AC   Q3LU39;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Homeobox protein prophet of Pit-1;
DE            Short=PROP-1;
DE   AltName: Full=Pituitary-specific homeodomain factor;
GN   Name=PROP1;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Camper S.A., Ward R.D., Cho M., Esposito C., Lyons R.H., Cheng J.-F.,
RA   Rubin E.M., Rhodes S.J., Raetzman L.T., Smith T.P.L.;
RT   "Comparative genomics reveal functional transcriptional control sequences
RT   in the Prop1 gene.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possibly involved in the ontogenesis of pituitary
CC       gonadotropes, as well as somatotropes, lactotropes and caudomedial
CC       thyrotropes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; DQ177426; ABA26453.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3LU39; -.
DR   SMR; Q3LU39; -.
DR   STRING; 9593.ENSGGOP00000025734; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; Q3LU39; -.
DR   Proteomes; UP000001519; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0021983; P:pituitary gland development; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR042412; PROP1.
DR   PANTHER; PTHR47409; PTHR47409; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..225
FT                   /note="Homeobox protein prophet of Pit-1"
FT                   /id="PRO_0000049270"
FT   DNA_BIND        69..128
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..217
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   225 AA;  24826 MW;  69BC5B656351D256 CRC64;
     MEAERRCQAE KPKKGRVGSS LLPERHPATG TLTTMVDSSA PPCRRLPGAG GGRSRFSPQG
     GQRGRPHSRR RHRTTFSPVQ LEQLESAFGR NQYPDIWARE SLARDTGLSE ARIQVWFQNR
     RAKQRKQECS LLQPLAHLSP AAFSSFLPES TACPYSYAPP PPVTCFPHPY SHALPSQPST
     GGAFALSHQS EDWYPTLHPA PAGHLPCPPP PPMLPLSLEP SKSWN