PROP1_PIG
ID PROP1_PIG Reviewed; 226 AA.
AC Q9GLL9; A2IBI2; Q5TLE9;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Homeobox protein prophet of Pit-1;
DE Short=PROP-1;
DE AltName: Full=Pituitary-specific homeodomain factor;
GN Name=PROP1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11064154; DOI=10.1016/s0303-7207(00)00318-x;
RA Sloop K.W., McCutchan Schiller A., Smith T.P.L., Blanton J.R. Jr.,
RA Rohrer G.A., Meier B.C., Rhodes S.J.;
RT "Biochemical and genetic characterization of the porcine Prophet of Pit-1
RT pituitary transcription factor.";
RL Mol. Cell. Endocrinol. 168:77-87(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary anterior lobe;
RX PubMed=15474519; DOI=10.1016/j.bbrc.2004.09.124;
RA Aikawa S., Kato T., Susa T., Tomizawa K., Ogawa S., Kato Y.;
RT "Pituitary transcription factor Prop-1 stimulates porcine follicle-
RT stimulating hormone beta subunit gene expression.";
RL Biochem. Biophys. Res. Commun. 324:946-952(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Heng W.N., Guo C.H.;
RT "Cloning and sequence analysis of Prop1 gene in WuZhiShan pig.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Possibly involved in the ontogenesis of pituitary
CC gonadotropes, as well as somatotropes, lactotropes and caudomedial
CC thyrotropes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in the developing pituitary
CC gland.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; AF232676; AAG33702.1; -; mRNA.
DR EMBL; AB187272; BAD72766.1; -; mRNA.
DR EMBL; EF188259; ABM63375.1; -; Genomic_DNA.
DR RefSeq; NP_001001263.1; NM_001001263.1.
DR AlphaFoldDB; Q9GLL9; -.
DR SMR; Q9GLL9; -.
DR STRING; 9823.ENSSSCP00000022383; -.
DR PaxDb; Q9GLL9; -.
DR PRIDE; Q9GLL9; -.
DR Ensembl; ENSSSCT00000028015; ENSSSCP00000022383; ENSSSCG00000029569.
DR Ensembl; ENSSSCT00005026366; ENSSSCP00005016020; ENSSSCG00005016744.
DR Ensembl; ENSSSCT00015083267; ENSSSCP00015033696; ENSSSCG00015062296.
DR Ensembl; ENSSSCT00025091153; ENSSSCP00025039960; ENSSSCG00025066385.
DR Ensembl; ENSSSCT00030029731; ENSSSCP00030013348; ENSSSCG00030021434.
DR Ensembl; ENSSSCT00035031245; ENSSSCP00035012233; ENSSSCG00035023806.
DR Ensembl; ENSSSCT00040059341; ENSSSCP00040024888; ENSSSCG00040044247.
DR Ensembl; ENSSSCT00045066927; ENSSSCP00045047514; ENSSSCG00045038575.
DR Ensembl; ENSSSCT00050060271; ENSSSCP00050025916; ENSSSCG00050044271.
DR Ensembl; ENSSSCT00055023072; ENSSSCP00055018245; ENSSSCG00055011786.
DR Ensembl; ENSSSCT00060089889; ENSSSCP00060038935; ENSSSCG00060065803.
DR Ensembl; ENSSSCT00065029335; ENSSSCP00065011977; ENSSSCG00065022055.
DR Ensembl; ENSSSCT00070054315; ENSSSCP00070046057; ENSSSCG00070027089.
DR GeneID; 397280; -.
DR KEGG; ssc:397280; -.
DR CTD; 5626; -.
DR VGNC; VGNC:91834; PROP1.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000162292; -.
DR HOGENOM; CLU_044912_1_0_1; -.
DR InParanoid; Q9GLL9; -.
DR OMA; EPPKSWN; -.
DR OrthoDB; 1351285at2759; -.
DR TreeFam; TF315976; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Proteomes; UP000314985; Chromosome 2.
DR Bgee; ENSSSCG00000029569; Expressed in oocyte and 5 other tissues.
DR ExpressionAtlas; Q9GLL9; baseline.
DR Genevisible; Q9GLL9; SS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0021983; P:pituitary gland development; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR042412; PROP1.
DR PANTHER; PTHR47409; PTHR47409; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..226
FT /note="Homeobox protein prophet of Pit-1"
FT /id="PRO_0000049273"
FT DNA_BIND 69..128
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..219
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 226 AA; 25214 MW; C86B2D74B83A90E8 CRC64;
MEAEGRREQG KPRKGRVCSS LWPEGYPAAG TLTARVDIST RPYRNLSGVG AGRPRLSPQG
GQRGRPHSRR RHRTTFSPAQ LEQLESAFGR NQYPDIWARE GLARDTGLSE ARIQVWFQNR
RAKQRKQERS LLQPLAHLSP ATFSGFLPEP PACPYSYPTP PPPMTCFPHP YNHALPSQPS
TGGSFARHPQ SEDWYPTLHP TPTGHLPCPP APPVLPLSLE PPKSWN
