ID   PROP1_THEGE             Reviewed;         226 AA.
AC   Q3LU41;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Homeobox protein prophet of Pit-1;
DE            Short=PROP-1;
DE   AltName: Full=Pituitary-specific homeodomain factor;
GN   Name=PROP1;
OS   Theropithecus gelada (Gelada baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Theropithecus.
OX   NCBI_TaxID=9565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Camper S.A., Ward R.D., Cho M., Esposito C., Lyons R.H., Cheng J.-F.,
RA   Rubin E.M., Rhodes S.J., Raetzman L.T., Smith T.P.L.;
RT   "Comparative genomics reveal functional transcriptional control sequences
RT   in the Prop1 gene.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possibly involved in the ontogenesis of pituitary
CC       gonadotropes, as well as somatotropes, lactotropes and caudomedial
CC       thyrotropes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; DQ177424; ABA26451.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3LU41; -.
DR   SMR; Q3LU41; -.
DR   Ensembl; ENSTGET00000024340; ENSTGEP00000020455; ENSTGEG00000016438.
DR   Proteomes; UP000694411; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0021983; P:pituitary gland development; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR042412; PROP1.
DR   PANTHER; PTHR47409; PTHR47409; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..226
FT                   /note="Homeobox protein prophet of Pit-1"
FT                   /id="PRO_0000049274"
FT   DNA_BIND        69..128
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..218
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  25049 MW;  1E9D4AAACB7E7630 CRC64;
     MEAERRRQAE KPKKGQVGSS LLPERHPAAG TLTTMVDSSA PPCRRLPGAG VGRPRFSPQG
     GQRGRPHSRR RHRTTFSPVQ LEQLESAFGR NQYPDIWARE SLARDTGLSE ARIQVWFQNR
     RAKQRKQERS LLQPLAHLSP AAFSSFLPES SACPYSYAPP PPPVTCFPHP YSHALPSQPS
     TGGAFALPHQ SEDWYPTLHP TPAGHLPCPP PPPMLPLSLE PSKSWN