PROP_STAAC
ID PROP_STAAC Reviewed; 466 AA.
AC Q5HIA2;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Putative proline/betaine transporter;
GN Name=proP; OrderedLocusNames=SACOL0620;
OS Staphylococcus aureus (strain COL).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93062;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COL;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: May be a proton symporter involved in the uptake of osmolytes
CC such as proline and glycine betaine. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Metabolite:H+
CC Symporter (MHS) family (TC 2.A.1.6) family. {ECO:0000305}.
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DR EMBL; CP000046; AAW37729.1; -; Genomic_DNA.
DR RefSeq; WP_000347061.1; NC_002951.2.
DR AlphaFoldDB; Q5HIA2; -.
DR SMR; Q5HIA2; -.
DR EnsemblBacteria; AAW37729; AAW37729; SACOL0620.
DR KEGG; sac:SACOL0620; -.
DR HOGENOM; CLU_001265_39_5_9; -.
DR OMA; FLVEMFP; -.
DR Proteomes; UP000000530; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..466
FT /note="Putative proline/betaine transporter"
FT /id="PRO_0000050327"
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 466 AA; 51658 MW; 29180E521AC8603D CRC64;
MDFNKENINM VDAKKAKKTV VATGIGNAME WFDFGVYAYT TAYIGANFFS PVENADIRQM
LTFAALAIAF LLRPIGGVVF GIIGDKYGRK VVLTSTIILM AFSTLTIGLL PSYDQIGLWA
PILLLLARVL QGFSTGGEYA GAMTYVAESS PDKRRNSLGS GLEIGTLSGY IAASIMIAVL
TFFLTDEQMA SFGWRIPFLL GLFLGLFGLY LRRKLEESPV FENDVATQPE RDNINFLQII
RFYYKDIFVC FVAVVFFNVT NYMVTAYLPT YLEQVIKLDA TTTSVLITCV MAIMIPLALM
FGKLADKIGE KKVFLIGTGG LTLFSIIAFM LLHSQSFVVI VIGIFILGFF LSTYEATMPG
SLPTMFYSHI RYRTLSVTFN ISVSIFGGTT PLVATWLVTK TGDPLAPAYY LTAISVIGFL
VITFLHLSTA GKSLKGSYPN VDNEQDRAYY AEHPKEALWW VKERKN