ID   PROP_STAEQ              Reviewed;         464 AA.
AC   Q5HRH0;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Putative proline/betaine transporter;
GN   Name=proP; OrderedLocusNames=SERP0223;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: May be a proton symporter involved in the uptake of osmolytes
CC       such as proline and glycine betaine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Metabolite:H+
CC       Symporter (MHS) family (TC 2.A.1.6) family. {ECO:0000305}.
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DR   EMBL; CP000029; AAW53603.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5HRH0; -.
DR   SMR; Q5HRH0; -.
DR   STRING; 176279.SERP0223; -.
DR   EnsemblBacteria; AAW53603; AAW53603; SERP0223.
DR   KEGG; ser:SERP0223; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_001265_39_0_9; -.
DR   OMA; FLVEMFP; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..464
FT                   /note="Putative proline/betaine transporter"
FT                   /id="PRO_0000050334"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   464 AA;  51718 MW;  23F47E463407DF72 CRC64;
     MVDGNNAKKT VIATGIGNAM EWFDFGLYSY LAVIISKNFF SQVDNDQLKL VFTFATFAIA
     FLLRPIGGIV FGIIGDKYGR KIVLTTTIIL MAFSTLLIGV LPTYNEIGVW APILLLLARV
     LQGFSTGGEY AGAMVYVAES SPDRKRNSLG CGLEIGTLSG YIAASILVFA LNISLTETQL
     NSWGWRIPFL LGMFLGLFGL YLRRKLEESP IYENEQRELQ KHPTREPIGV FTLIRFYYKD
     IIVCFVAVAF FNVTNYMVTA YLPSYLEGVI KLNGTTTSIM ITCIMVIMIP LALMFGRIAD
     RIGEKKVFLI GLGGLILLSV VAFSLMQLQS LFFVSIGVLI LGFFLSTYEA TMPGSLPTMF
     YTHVRYRALA ITFNVSVSLL GGTTPLIASY LVSTTNNPLT PAYYLTVISI IGFIVIALLH
     KSTASKSLKG SYPNVDNEKD REYYEKNPEQ ALWWLKERQE KEKF