ID   PROP_STAHJ              Reviewed;         468 AA.
AC   Q4L3Q4;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Putative proline/betaine transporter;
GN   Name=proP; OrderedLocusNames=SH2414;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: May be a proton symporter involved in the uptake of osmolytes
CC       such as proline and glycine betaine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Metabolite:H+
CC       Symporter (MHS) family (TC 2.A.1.6) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP006716; BAE05723.1; -; Genomic_DNA.
DR   RefSeq; WP_011276669.1; NC_007168.1.
DR   AlphaFoldDB; Q4L3Q4; -.
DR   SMR; Q4L3Q4; -.
DR   STRING; 279808.SH2414; -.
DR   EnsemblBacteria; BAE05723; BAE05723; SH2414.
DR   GeneID; 58061557; -.
DR   KEGG; sha:SH2414; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_001265_39_5_9; -.
DR   OMA; FLVEMFP; -.
DR   OrthoDB; 961781at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..468
FT                   /note="Putative proline/betaine transporter"
FT                   /id="PRO_0000050335"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   468 AA;  51668 MW;  B6435004DAE6EEC5 CRC64;
     MDFKKDRINM VDGQTAKKTV FATGIGNAME WFDFGVYAYT TAYIGANFFS PVQNPEIQQI
     FTFAALAIAF LLRPIGGIVF GIIGDKYGRK VVLTTTIILM ALSTLTIGVL PNYDMIGLWA
     PALLLLARIL QGFSTGGEYA GAMTYIAEIS PDKKRNSLGS GLEIGTLSGY IAASIMIALL
     SFFLSDAQME AWGWRIPFIL GLFLGLFGLY LRRKLEESPI YENDVETPAR DNIGFFTIIR
     YYFKDILVCF VAVVFFNVTN YTVTAYLPTY LGQIVKIDET TTSVLITCVM AVMIPLALFF
     GKLADKIGEK KVFLIGTGGL TLLSIVAFSL LNTKSLPFII LGVFILGFFL STYEATMPGS
     LPTMFFTHIR YRTLAVTFNI SVSLFGGTTP LVNSWLVEST GNIYAPAYYL TAISIIGFIV
     IAVLHVSTAG KSLKGSYPNV DNKKDLEFYE SNPKKALWWI KVKKNKNA