AAC2_DICDI
ID AAC2_DICDI Reviewed; 464 AA.
AC P14196; Q54NT7;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=AAC-rich mRNA clone AAC11 protein;
GN Name=AAC11; ORFNames=DDB_G0284871;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 17-464.
RX PubMed=2511421; DOI=10.1007/bf00332409;
RA Shaw D.R., Richter H., Giorda R., Ohmachi T., Ennis H.L.;
RT "Nucleotide sequences of Dictyostelium discoideum developmentally regulated
RT cDNAs rich in (AAC) imply proteins that contain clusters of asparagine,
RT glutamine, or threonine.";
RL Mol. Gen. Genet. 218:453-459(1989).
CC -!- DEVELOPMENTAL STAGE: The concentration of AAC-rich mRNAs is low in
CC dormant spores and growing cells, but increases during spore-
CC germination and multicellular development.
CC -!- MISCELLANEOUS: Several proteins derive from AAC-rich mRNA, which, due
CC to a frameshift also have ACA and CAA codons and thus are Asn-, Thr- or
CC Gln-rich.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA34529.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AAFI02000073; EAL64899.1; -; Genomic_DNA.
DR EMBL; X16522; CAA34529.1; ALT_FRAME; mRNA.
DR PIR; S05355; S05355.
DR RefSeq; XP_639980.1; XM_634888.1.
DR AlphaFoldDB; P14196; -.
DR STRING; 44689.DDB0191407; -.
DR PaxDb; P14196; -.
DR EnsemblProtists; EAL64899; EAL64899; DDB_G0284871.
DR GeneID; 8624893; -.
DR KEGG; ddi:DDB_G0284871; -.
DR dictyBase; DDB_G0284871; -.
DR eggNOG; ENOG502RHZ6; Eukaryota.
DR HOGENOM; CLU_589784_0_0_1; -.
DR OMA; NANNRRM; -.
DR PRO; PR:P14196; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0000785; C:chromatin; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR000116; HMGA.
DR Pfam; PF02178; AT_hook; 4.
DR PRINTS; PR00929; ATHOOK.
DR PRINTS; PR00930; HIGHMOBLTYIY.
DR SMART; SM00384; AT_hook; 4.
PE 2: Evidence at transcript level;
KW DNA-binding; Reference proteome; Repeat.
FT CHAIN 1..464
FT /note="AAC-rich mRNA clone AAC11 protein"
FT /id="PRO_0000206716"
FT DNA_BIND 177..189
FT /note="A.T hook 1"
FT DNA_BIND 198..210
FT /note="A.T hook 2"
FT DNA_BIND 224..236
FT /note="A.T hook 3"
FT DNA_BIND 255..267
FT /note="A.T hook 4"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 267
FT /note="D -> E (in Ref. 2; CAA34529)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 464 AA; 50619 MW; 2D50A1A2AA4DDD4A CRC64;
MSTPTLPNLS QLHGIQNQSL QQQQQQQPQQ QQQPQQQQQQ QQPQQTMQQP IQNLHQQAPQ
MQQPQYNLHT TLPPPLMNPN GLGLMGHNMM GGGNNGNNSG NNNGQPQMHG TNLNGLSLAI
QNQSSLPQPI NNNNNNNNNN SNINNNNNNS NNNNNNNNSN LGINSSPTQS SANSADKRSR
GRPRKNPPSE PKDTSGPKRK RGRPPKMDEE GNPQPKPVPQ PGSNKKRGRP KKPKDENESD
YNNTSFSDSN TDGTPKKRGR PPKAKGDSPS ASPTHNTLGN GILNSNNNNN NNNNNSNINN
INNNNNNNSN NNNNSSNNNN NNNNSTNNNT NNNNNNTNNN TNNNNNNINN NNNNTNNNNN
NANNQNTNNN NMGNNSNNNN NPNNNNHQNN NNNNTSNNSN TTTATTTAPG GNNLTNSLNN
AGNLGNLGRV SGLHSSDPNN PNAQKSFPDS TNTMDFQPNF SFFH
