PROQ_ECOSM
ID PROQ_ECOSM Reviewed; 232 AA.
AC B1LD41;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=RNA chaperone ProQ {ECO:0000255|HAMAP-Rule:MF_00749};
GN Name=proQ {ECO:0000255|HAMAP-Rule:MF_00749};
GN OrderedLocusNames=EcSMS35_1356;
OS Escherichia coli (strain SMS-3-5 / SECEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=439855;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SMS-3-5 / SECEC;
RX PubMed=18708504; DOI=10.1128/jb.00661-08;
RA Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA Ravel J., Stepanauskas R.;
RT "Insights into the environmental resistance gene pool from the genome
RT sequence of the multidrug-resistant environmental isolate Escherichia coli
RT SMS-3-5.";
RL J. Bacteriol. 190:6779-6794(2008).
CC -!- FUNCTION: RNA chaperone with significant RNA binding, RNA strand
CC exchange and RNA duplexing activities. May regulate ProP activity
CC through an RNA-based, post-transcriptional mechanism.
CC {ECO:0000255|HAMAP-Rule:MF_00749}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00749}.
CC -!- SIMILARITY: Belongs to the ProQ family. {ECO:0000255|HAMAP-
CC Rule:MF_00749}.
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DR EMBL; CP000970; ACB18791.1; -; Genomic_DNA.
DR RefSeq; WP_000431370.1; NC_010498.1.
DR AlphaFoldDB; B1LD41; -.
DR SMR; B1LD41; -.
DR EnsemblBacteria; ACB18791; ACB18791; EcSMS35_1356.
DR GeneID; 66674279; -.
DR KEGG; ecm:EcSMS35_1356; -.
DR HOGENOM; CLU_113254_0_0_6; -.
DR OMA; WRYLKGV; -.
DR Proteomes; UP000007011; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0033592; F:RNA strand annealing activity; IEA:UniProtKB-UniRule.
DR GO; GO:0034057; F:RNA strand-exchange activity; IEA:UniProtKB-UniRule.
DR GO; GO:0010608; P:post-transcriptional regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.10.1710.10; -; 1.
DR HAMAP; MF_00749; ProQ; 1.
DR InterPro; IPR023529; ProQ.
DR InterPro; IPR016103; ProQ/FinO.
DR InterPro; IPR036442; ProQ/FinO_sf.
DR InterPro; IPR035236; ProQ_C.
DR PANTHER; PTHR38106; PTHR38106; 1.
DR Pfam; PF04352; ProQ; 1.
DR Pfam; PF17516; ProQ_C; 1.
DR SMART; SM00945; ProQ; 1.
DR SUPFAM; SSF48657; SSF48657; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; RNA-binding.
FT CHAIN 1..232
FT /note="RNA chaperone ProQ"
FT /id="PRO_1000133296"
FT REGION 105..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 232 AA; 25862 MW; 1E8AFBA345A3C728 CRC64;
MENQPKLNSS KEVIAFLAER FPHCFSAEGE ARPLKIGIFQ DLVDRVAGEM NLSKTQLRSA
LRLYTSSWRY LYGVKPGATR VDLDGNPCGE LDEQHVEHAR KQLEEAKARV QAQRAEQQAK
KREAAAAAGE KEDAPRRERK PRPTTPRRKE GAERKPRAQK PVEKAPKTVK APREEQHTPV
SDISALTVGQ ALKVKAGQNA MDATVLEITK DGVRVQLNSG MSLIVRAEHL VF