PROX1_CHICK
ID PROX1_CHICK Reviewed; 736 AA.
AC Q91018;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Prospero homeobox protein 1;
DE AltName: Full=Homeobox prospero-like protein PROX1;
DE Short=PROX-1;
GN Name=PROX1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Embryonic lens;
RX PubMed=8853985;
RX DOI=10.1002/(sici)1097-0177(199608)206:4<354::aid-aja2>3.0.co;2-h;
RA Tomarev S.I., Sundin O., Banerjee-Basu S., Duncan M.K., Yang J.-M.,
RA Piatigorsky J.;
RT "Chicken homeobox gene Prox 1 related to Drosophila prospero is expressed
RT in the developing lens and retina.";
RL Dev. Dyn. 206:354-367(1996).
RN [2]
RP ERRATUM OF PUBMED:8853985.
RA Tomarev S.I., Sundin O., Banerjee-Basu S., Duncan M.K., Yang J.-M.,
RA Piatigorsky J.;
RL Dev. Dyn. 207:120-120(1996).
CC -!- FUNCTION: Transcription factor which may be involved in developmental
CC processes such as cell fate determination, gene transcriptional
CC regulation and progenitor cell regulation in a number of organs. May be
CC essential in the development and function of the eye. May play a role
CC in the regulation of the circadian rhythm by repressing the expression
CC of clock genes. {ECO:0000250|UniProtKB:P48437,
CC ECO:0000303|PubMed:8853985}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Comment=Additional isoforms seem to exist.;
CC Name=Long;
CC IsoId=Q91018-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=Q91018-2; Sequence=VSP_002305;
CC -!- TISSUE SPECIFICITY: Expressed most actively in the developing lens and
CC midgut and at lower levels in the developing brain, heart, muscle and
CC retina. {ECO:0000269|PubMed:8853985}.
CC -!- DEVELOPMENTAL STAGE: First detected at stage 14 in the early lens
CC placode. At later stages of development, it was observed throughout the
CC lens, but it appeared more abundant around the bow region of the
CC equator than in the anterior epithelium or the fibers. In the retina,
CC expression was detected mainly in the inner nuclear layer during later
CC stages of histogenesis. {ECO:0000269|PubMed:8853985}.
CC -!- DOMAIN: The Prospero-type homeodomain and the adjacent Prospero domain
CC act as a single structural unit, the Homeo-Prospero domain.
CC {ECO:0000255|PROSITE-ProRule:PRU01162}.
CC -!- SIMILARITY: Belongs to the Prospero homeodomain family.
CC {ECO:0000255|PROSITE-ProRule:PRU01162}.
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DR EMBL; U46563; AAC59938.1; -; mRNA.
DR PIR; JC5495; JC5495.
DR RefSeq; NP_001005616.1; NM_001005616.1. [Q91018-1]
DR AlphaFoldDB; Q91018; -.
DR BMRB; Q91018; -.
DR SMR; Q91018; -.
DR STRING; 9031.ENSGALP00000015910; -.
DR PaxDb; Q91018; -.
DR GeneID; 395802; -.
DR KEGG; gga:395802; -.
DR CTD; 5629; -.
DR VEuPathDB; HostDB:geneid_395802; -.
DR eggNOG; KOG3779; Eukaryota.
DR InParanoid; Q91018; -.
DR OrthoDB; 373478at2759; -.
DR PhylomeDB; Q91018; -.
DR PRO; PR:Q91018; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IDA:BHF-UCL.
DR GO; GO:0005634; C:nucleus; IDA:BHF-UCL.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0055013; P:cardiac muscle cell development; IEP:BHF-UCL.
DR GO; GO:0021516; P:dorsal spinal cord development; IEP:BHF-UCL.
DR GO; GO:0007507; P:heart development; IEP:BHF-UCL.
DR GO; GO:0070365; P:hepatocyte differentiation; IEP:BHF-UCL.
DR GO; GO:0001822; P:kidney development; IEP:BHF-UCL.
DR GO; GO:0002088; P:lens development in camera-type eye; IEP:BHF-UCL.
DR GO; GO:0070309; P:lens fiber cell morphogenesis; IEP:BHF-UCL.
DR GO; GO:0001889; P:liver development; IEP:BHF-UCL.
DR GO; GO:0001945; P:lymph vessel development; IEP:BHF-UCL.
DR GO; GO:0001946; P:lymphangiogenesis; IEP:BHF-UCL.
DR GO; GO:0021915; P:neural tube development; IEP:BHF-UCL.
DR GO; GO:0030910; P:olfactory placode formation; IEP:BHF-UCL.
DR GO; GO:0043049; P:otic placode formation; IEP:BHF-UCL.
DR GO; GO:0031016; P:pancreas development; IEP:BHF-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060042; P:retina morphogenesis in camera-type eye; IEP:BHF-UCL.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.500; -; 1.
DR InterPro; IPR023082; Homeo_prospero_dom.
DR InterPro; IPR037131; Homeo_prospero_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR039350; Prospero_homeodomain.
DR InterPro; IPR007738; Prox1.
DR PANTHER; PTHR12198; PTHR12198; 1.
DR PANTHER; PTHR12198:SF6; PTHR12198:SF6; 1.
DR Pfam; PF05044; HPD; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51818; HOMEO_PROSPERO; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Biological rhythms; Developmental protein;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..736
FT /note="Prospero homeobox protein 1"
FT /id="PRO_0000208882"
FT DOMAIN 576..634
FT /note="Prospero-type homeo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01162"
FT DOMAIN 635..734
FT /note="Prospero"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01162"
FT REGION 103..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..734
FT /note="Homeo-Prospero"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01162"
FT MOTIF 163..168
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 103..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 611..675
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_002305"
SQ SEQUENCE 736 AA; 83141 MW; 8723ED53B3435160 CRC64;
MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS EQDVEYSVVQ
HADGEKPNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN MNKNGGTEPS FQASGLSSTG
SEVHQEDVCS NSSRDSPQEC LSPFGRPTMS QFDVDRLCDE HLRAKRARVE NIIRGMSHSP
RVALRGNENE REIRPQSVSP RESYRENKRK QNWPQQQQQS FQQLVSARKE QKREERRQLK
QQLEDMQKQL RQLQEEFYQI YDSTDSENDE DGNLSEDRMR SETVDAQAGD SVGRSDNEMC
ELDPGQFIDR ARALIREQEI GENKPKREGP KEKDQGPNSF HPEGKHLAET LKQELNTAMS
QVVDTVVKVF SSKPSRQLPQ VFPPLQIPQA RFAVNGENHN FHTANQRLQC FGDVIIPNPL
DTFSSVPMPG ATDQTDALPL VVRKNSSDQP ASAPPAGGHH ASLHQSPLSA TAGFSTSSFR
HPFPLPLMAY PFQSPLGAPS ASFPGKERAS PESLDLTRET TSLRTKMSSH HMNHHPCSPA
HPPSAAEGLS LSLIKSECGD LQDMSEISPY SGSAMQEGLS PNHLKKAKLM FFYTRYPSSN
MLKTYFSDVK FNRCITSQLI KWFSNFREFY YIQMEKYARQ AINDGVTSTE ELSITRDCEL
YRALNMHYNK ANDFEVPERF LEVAQITLRE FFNAIIAGKD VDPSWKKAIY KVICKLDSEV
PEIFKSPNCL QELLHE
