PROX2_MOUSE
ID PROX2_MOUSE Reviewed; 593 AA.
AC Q8BII1;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Prospero homeobox protein 2;
DE AltName: Full=Homeobox prospero-like protein PROX2;
DE Short=PROX-2;
GN Name=Prox2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=16470382; DOI=10.1007/s00438-006-0105-0;
RA Nishijima I., Ohtoshi A.;
RT "Characterization of a novel prospero-related homeobox gene, Prox2.";
RL Mol. Genet. Genomics 275:471-478(2006).
CC -!- FUNCTION: Transcription regulator. Does not seem to be essential for
CC embryonic development and postnatal survival.
CC {ECO:0000269|PubMed:16470382}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:16470382}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing nervous system.
CC Expressed at 9.5 dpc in the geniculate (VIIth), petrosal (IXth), and
CC nodose (Xth) ganglia. Expressed in postnatal eyes.
CC {ECO:0000269|PubMed:16470382}.
CC -!- DOMAIN: The Prospero-type homeodomain and the adjacent Prospero domain
CC act as a single structural unit, the Homeo-Prospero domain.
CC {ECO:0000255|PROSITE-ProRule:PRU01162}.
CC -!- DISRUPTION PHENOTYPE: Mice grow normally and body weight was similar to
CC that of wild type. Heterozygous mutant mice survived to adulthood and
CC appeared normal. {ECO:0000269|PubMed:16470382}.
CC -!- SIMILARITY: Belongs to the Prospero homeodomain family.
CC {ECO:0000255|PROSITE-ProRule:PRU01162}.
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DR EMBL; AK051700; BAC34725.1; -; mRNA.
DR EMBL; BC119330; AAI19331.1; -; mRNA.
DR EMBL; BC119332; AAI19333.1; -; mRNA.
DR CCDS; CCDS36495.1; -.
DR RefSeq; NP_780407.1; NM_175198.4.
DR RefSeq; XP_006516341.1; XM_006516278.3.
DR RefSeq; XP_006516342.1; XM_006516279.3.
DR RefSeq; XP_006516344.1; XM_006516281.3.
DR RefSeq; XP_011242489.1; XM_011244187.2.
DR RefSeq; XP_017170702.1; XM_017315213.1.
DR AlphaFoldDB; Q8BII1; -.
DR SMR; Q8BII1; -.
DR BioGRID; 216004; 2.
DR IntAct; Q8BII1; 2.
DR STRING; 10090.ENSMUSP00000105878; -.
DR PhosphoSitePlus; Q8BII1; -.
DR MaxQB; Q8BII1; -.
DR PaxDb; Q8BII1; -.
DR PRIDE; Q8BII1; -.
DR ProteomicsDB; 291662; -.
DR Antibodypedia; 50733; 77 antibodies from 14 providers.
DR DNASU; 73422; -.
DR Ensembl; ENSMUST00000110249; ENSMUSP00000105878; ENSMUSG00000042320.
DR Ensembl; ENSMUST00000177289; ENSMUSP00000135881; ENSMUSG00000042320.
DR GeneID; 73422; -.
DR KEGG; mmu:73422; -.
DR UCSC; uc033ged.1; mouse.
DR CTD; 283571; -.
DR MGI; MGI:1920672; Prox2.
DR VEuPathDB; HostDB:ENSMUSG00000042320; -.
DR eggNOG; KOG3779; Eukaryota.
DR GeneTree; ENSGT00940000154790; -.
DR HOGENOM; CLU_016051_1_0_1; -.
DR InParanoid; Q8BII1; -.
DR OMA; HIQENQI; -.
DR OrthoDB; 373478at2759; -.
DR PhylomeDB; Q8BII1; -.
DR TreeFam; TF316638; -.
DR BioGRID-ORCS; 73422; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8BII1; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8BII1; protein.
DR Bgee; ENSMUSG00000042320; Expressed in spermatid and 81 other tissues.
DR Genevisible; Q8BII1; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.500; -; 1.
DR InterPro; IPR023082; Homeo_prospero_dom.
DR InterPro; IPR037131; Homeo_prospero_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR039350; Prospero_homeodomain.
DR PANTHER; PTHR12198; PTHR12198; 1.
DR Pfam; PF05044; HPD; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51818; HOMEO_PROSPERO; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..593
FT /note="Prospero homeobox protein 2"
FT /id="PRO_0000342678"
FT DOMAIN 433..491
FT /note="Prospero-type homeo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01162"
FT DOMAIN 492..591
FT /note="Prospero"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01162"
FT REGION 24..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..591
FT /note="Homeo-Prospero"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01162"
FT COMPBIAS 90..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 65759 MW; 150D1DCDB0BD9719 CRC64;
MDPPAAVLLP PQSRTCTHLA EETCMDQERS PATAEAGRDS FPSGQLPSSS LTEADWFWDE
HIQAKRARVE TIVRGMCLSP SSSVSGRARE SLRCPEKGRE RKRKQSLPMH QGPLKSSPAW
ERGPKKGGTR VKEQLHLLKQ QLRHLQEHVL QATEPRAPAQ SPGGTEPRSS PRARPRNSCS
SGAWTVENEP HQSSSKDLCG AVKPGAAEVL QYSEEPMLCP SGPRALVETL RKELSRAVSQ
AVDSVLQQVL FDPQRHLTQQ ERSCQGLASE GRNQPSPPGR SAYKDPLALA TLPRKIQPQA
GVPLGNSTLA RPLDSPMCPV SPRGVPRSYQ SPLPNCPLTN VPSHTWENQM LRQLLGRGPD
GQWSGSPPQD AAFQSHTSPE SAQQPWGLSQ QQLPLSLTPV HLESRPLPPP VKMEQGVLRG
VADSLPFSSI HIQEGLSPGH LKKAKLMFFF TRYPSSSLLK AYFPDVQFNR CITSQMIKWF
SNFREFYYIQ MEKYARQALS DGITNAQALA VLRDSELFRV LNTHYNKGND FEVPDCFLEI
AALTLKEFFR AVLAGKDSDP SWKKPIYKVI SKLDSDVPEM LKSPSFLPGL FPS
