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PRP17_SCHPO
ID   PRP17_SCHPO             Reviewed;         558 AA.
AC   O43071;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 151.
DE   RecName: Full=Pre-mRNA-processing factor 17;
GN   Name=prp17; ORFNames=SPBC6B1.10;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   IDENTIFICATION IN THE CWF COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=11884590; DOI=10.1128/mcb.22.7.2011-2024.2002;
RA   Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L.;
RT   "Proteomics analysis reveals stable multiprotein complexes in both fission
RT   and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA
RT   splicing factors, and snRNAs.";
RL   Mol. Cell. Biol. 22:2011-2024(2002).
RN   [3]
RP   FUNCTION.
RX   PubMed=15452114; DOI=10.1074/jbc.m408815200;
RA   Sapra A.K., Arava Y., Khandelia P., Vijayraghavan U.;
RT   "Genome-wide analysis of pre-mRNA splicing: intron features govern the
RT   requirement for the second-step factor, Prp17 in Saccharomyces cerevisiae
RT   and Schizosaccharomyces pombe.";
RL   J. Biol. Chem. 279:52437-52446(2004).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Functions in the second step of pre-mRNA splicing. Involved
CC       in splicing intron which are longer than 200 nucleotides.
CC       {ECO:0000269|PubMed:15452114}.
CC   -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC       spliceosome sub-complex reminiscent of a late-stage spliceosome
CC       composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5,
CC       cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27,
CC       cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16,
CC       cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26,
CC       cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10,
CC       prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1,
CC       smd1, smd3, smf1, smg1 and syf2. {ECO:0000269|PubMed:11884590}.
CC   -!- INTERACTION:
CC       O43071; O14011: prp19; NbExp=5; IntAct=EBI-538927, EBI-590830;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
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DR   EMBL; CU329671; CAA17053.1; -; Genomic_DNA.
DR   PIR; T40651; T40651.
DR   RefSeq; NP_596089.1; NM_001022004.2.
DR   PDB; 3JB9; EM; 3.60 A; g=1-558.
DR   PDBsum; 3JB9; -.
DR   AlphaFoldDB; O43071; -.
DR   SMR; O43071; -.
DR   BioGRID; 277683; 86.
DR   IntAct; O43071; 41.
DR   STRING; 4896.SPBC6B1.10.1; -.
DR   iPTMnet; O43071; -.
DR   MaxQB; O43071; -.
DR   PaxDb; O43071; -.
DR   PRIDE; O43071; -.
DR   EnsemblFungi; SPBC6B1.10.1; SPBC6B1.10.1:pep; SPBC6B1.10.
DR   PomBase; SPBC6B1.10; prp17.
DR   VEuPathDB; FungiDB:SPBC6B1.10; -.
DR   eggNOG; KOG0282; Eukaryota.
DR   HOGENOM; CLU_022571_2_1_1; -.
DR   InParanoid; O43071; -.
DR   OMA; EQTCYIP; -.
DR   PhylomeDB; O43071; -.
DR   Reactome; R-SPO-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-SPO-72187; mRNA 3'-end processing.
DR   PRO; PR:O43071; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IDA:PomBase.
DR   GO; GO:0000974; C:Prp19 complex; IDA:PomBase.
DR   GO; GO:0005681; C:spliceosomal complex; IDA:PomBase.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; ISS:PomBase.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR032847; PRPF17.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR43979; PTHR43979; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   3D-structure; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Repeat; Spliceosome; WD repeat.
FT   CHAIN           1..558
FT                   /note="Pre-mRNA-processing factor 17"
FT                   /id="PRO_0000278391"
FT   REPEAT          264..304
FT                   /note="WD 1"
FT   REPEAT          308..349
FT                   /note="WD 2"
FT   REPEAT          351..391
FT                   /note="WD 3"
FT   REPEAT          394..433
FT                   /note="WD 4"
FT   REPEAT          437..476
FT                   /note="WD 5"
FT   REPEAT          484..523
FT                   /note="WD 6"
FT   REPEAT          526..558
FT                   /note="WD 7"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..145
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..190
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   558 AA;  63132 MW;  78859607D4460195 CRC64;
     MLVANYSSDS EEQENSQSPN IQPLLHTENL APAVVDNVKD DLIVSKGGNS RELARNVPVN
     EMVQPALGPA NPFVTKEQDS IKNSITGYAE REYVPNFVFN QEYYANTHAI YGKRNFDDNE
     ATTSTDLKRK SQKIKERRED PGDPSILEGD GAYKGPWAGY GSEQSSSPLE YSEYEEVESL
     DVKSEKDTES NNLGQNELLK EQLATPEVET HRSKEETILH KDRLFDYQNR SYMHVPNDVG
     INLSEEPGEQ TCYIPKKHIF TWKGHTKGIS CLRFFPISGH LLLSGSMDNQ IKIWEVYHDR
     SLLRTFQGHA RPIRDLSFSQ DGRSFLSTSF DKTIKLWDTE LGKCLNCFNS DRLTNCVKFQ
     VDPDKPNEFL AGTADKRILQ FDIRSPDIVQ AYDHHLGGIN SITFLENGKR FVTTSDDSSM
     RFWEYGTPVP IKFVADIAMH SMPRVALRPN GKSIACQSLD NCIYVYSAYE KYRQNKKKVF
     KGYSCSGYSL EVGFSPDGRF VFSGDSSGNA CFWDWKTCKL MAKLPAHSGP VQSMAFHPQE
     TSKVATSSIV DGSIKYWD
 
 
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