ID   PRP18_BOVIN             Reviewed;         342 AA.
AC   Q2HJ41;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Pre-mRNA-splicing factor 18;
DE   AltName: Full=PRP18 homolog;
GN   Name=PRPF18;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in the second step of pre-mRNA splicing.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with PPIH. Interacts with PRPF4 and with the
CC       spliceosome. Part of a complex containing U4/U6 snRNPs (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Note=Colocalizes
CC       with spliceosomal snRNPs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PRP18 family. {ECO:0000305}.
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DR   EMBL; BC113323; AAI13324.1; -; mRNA.
DR   RefSeq; NP_001068791.1; NM_001075323.1.
DR   AlphaFoldDB; Q2HJ41; -.
DR   BMRB; Q2HJ41; -.
DR   SMR; Q2HJ41; -.
DR   STRING; 9913.ENSBTAP00000022912; -.
DR   PaxDb; Q2HJ41; -.
DR   PRIDE; Q2HJ41; -.
DR   Ensembl; ENSBTAT00000022912; ENSBTAP00000022912; ENSBTAG00000017244.
DR   GeneID; 507639; -.
DR   KEGG; bta:507639; -.
DR   CTD; 8559; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017244; -.
DR   eggNOG; KOG2808; Eukaryota.
DR   GeneTree; ENSGT00390000015073; -.
DR   HOGENOM; CLU_039675_0_1_1; -.
DR   InParanoid; Q2HJ41; -.
DR   OMA; SFAQVRW; -.
DR   OrthoDB; 1485522at2759; -.
DR   TreeFam; TF315049; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000017244; Expressed in oocyte and 105 other tissues.
DR   ExpressionAtlas; Q2HJ41; baseline and differential.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0071021; C:U2-type post-spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR   GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR   GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IBA:GO_Central.
DR   Gene3D; 4.10.280.110; -; 1.
DR   InterPro; IPR004098; Prp18.
DR   InterPro; IPR014906; PRP4-like.
DR   InterPro; IPR036285; PRP4-like_sf.
DR   InterPro; IPR039979; PRPF18.
DR   PANTHER; PTHR13007; PTHR13007; 1.
DR   Pfam; PF02840; Prp18; 1.
DR   Pfam; PF08799; PRP4; 1.
DR   SMART; SM00500; SFM; 1.
DR   SUPFAM; SSF158230; SSF158230; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..342
FT                   /note="Pre-mRNA-splicing factor 18"
FT                   /id="PRO_0000324099"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99633"
SQ   SEQUENCE   342 AA;  39832 MW;  5BFD2D10736B3A7F CRC64;
     MDVLKSEILR KRQLVEDRNL LVENKKYFKR SELAKKEEEA YFERCGYKIQ PKDEDQKPLT
     SSNPVLELEL AEEKLPMTLS RQEVIRRLRE RGEPIRLFGE TDYDAFQRLR KIEILTPEVN
     KGLRNDLKAA LDKIDQQYLN ELVGGQEPGE EDTQNDLKVH EENTTIEELE ALGESLGKGD
     DHKDMDIITK FLKFLLGVWA KELNAREDYV KRSVQGKLNS ATQKQTESYL RPLFRKLRKR
     NLPADIKESI TDIIKFMLQR EYVKANDAYL QMAIGNAPWP IGVTMVGIHA RTGREKIFSK
     HVAHVLNDET QRKYIQGLKR LMTICQKHFP TDPSKCVEYN AL