ID   PRP18_DANRE             Reviewed;         342 AA.
AC   Q6GMH0; A3KPM2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Pre-mRNA-splicing factor 18;
DE   AltName: Full=PRP18 homolog;
GN   Name=prpf18; ORFNames=si:ch211-220f12.3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in the second step of pre-mRNA splicing.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the spliceosome. Part of a complex containing
CC       U4/U6 snRNPs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Note=Colocalizes
CC       with spliceosomal snRNPs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PRP18 family. {ECO:0000305}.
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DR   EMBL; BX248392; CAM56405.1; -; Genomic_DNA.
DR   EMBL; BC074081; AAH74081.1; -; mRNA.
DR   RefSeq; NP_001002204.1; NM_001002204.1.
DR   AlphaFoldDB; Q6GMH0; -.
DR   SMR; Q6GMH0; -.
DR   STRING; 7955.ENSDARP00000075597; -.
DR   PaxDb; Q6GMH0; -.
DR   GeneID; 431751; -.
DR   KEGG; dre:431751; -.
DR   CTD; 8559; -.
DR   ZFIN; ZDB-GENE-040704-45; prpf18.
DR   eggNOG; KOG2808; Eukaryota.
DR   InParanoid; Q6GMH0; -.
DR   OrthoDB; 1485522at2759; -.
DR   PhylomeDB; Q6GMH0; -.
DR   TreeFam; TF315049; -.
DR   PRO; PR:Q6GMH0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0071021; C:U2-type post-spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR   GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR   GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IBA:GO_Central.
DR   Gene3D; 4.10.280.110; -; 1.
DR   InterPro; IPR004098; Prp18.
DR   InterPro; IPR014906; PRP4-like.
DR   InterPro; IPR036285; PRP4-like_sf.
DR   InterPro; IPR039979; PRPF18.
DR   PANTHER; PTHR13007; PTHR13007; 1.
DR   Pfam; PF02840; Prp18; 1.
DR   Pfam; PF08799; PRP4; 1.
DR   SMART; SM00500; SFM; 1.
DR   SUPFAM; SSF158230; SSF158230; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..342
FT                   /note="Pre-mRNA-splicing factor 18"
FT                   /id="PRO_0000324101"
FT   CONFLICT        178
FT                   /note="N -> T (in Ref. 2; CAM56405)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   342 AA;  39541 MW;  7CC16EDB4ECEE610 CRC64;
     MDILKAEIAR KRKLIEEKEL IDDSKKYFKR AELARKEEED YYRRCGYKMD KPEEEAPQST
     SANPVLELEL TEEKLPMTLS RQEVIRRLRE RGEPIRLFGE SDYDAFQRLR KIEILAPEVN
     KGLRNDLKAA MDKIDQQYLN EIVGGAEGAE LDTQHDLKVH EENTTIEELE ALGASLGNGN
     DVRDMDIINK VLRFLLGVWA KDLNSREDHI KRSVQGKLAS ATQKQTESYL EPLFRKLRKK
     NLPADIKESI TDIIKFMLER EYVKANDAYL QMAIGNAPWP IGVTMVGIHA RTGREKIFSK
     HVAHVLNDET QRKYIQGLKR LMTICQKHFP TDPSKCVEYN AL