ID   PRP18_PONAB             Reviewed;         342 AA.
AC   Q5RE03;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Pre-mRNA-splicing factor 18;
DE   AltName: Full=PRP18 homolog;
GN   Name=PRPF18;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in the second step of pre-mRNA splicing.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with PPIH. Interacts with PRPF4 and with the
CC       spliceosome. Part of a complex containing U4/U6 snRNPs (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Note=Colocalizes
CC       with spliceosomal snRNPs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PRP18 family. {ECO:0000305}.
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DR   EMBL; CR857737; CAH90004.1; -; mRNA.
DR   RefSeq; NP_001124950.1; NM_001131478.2.
DR   AlphaFoldDB; Q5RE03; -.
DR   BMRB; Q5RE03; -.
DR   SMR; Q5RE03; -.
DR   STRING; 9601.ENSPPYP00000002439; -.
DR   PRIDE; Q5RE03; -.
DR   Ensembl; ENSPPYT00000002513; ENSPPYP00000002439; ENSPPYG00000002101.
DR   GeneID; 100171822; -.
DR   KEGG; pon:100171822; -.
DR   CTD; 8559; -.
DR   eggNOG; KOG2808; Eukaryota.
DR   GeneTree; ENSGT00390000015073; -.
DR   HOGENOM; CLU_039675_0_1_1; -.
DR   InParanoid; Q5RE03; -.
DR   OMA; SFAQVRW; -.
DR   OrthoDB; 1485522at2759; -.
DR   TreeFam; TF315049; -.
DR   Proteomes; UP000001595; Chromosome 10.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.280.110; -; 1.
DR   InterPro; IPR004098; Prp18.
DR   InterPro; IPR014906; PRP4-like.
DR   InterPro; IPR036285; PRP4-like_sf.
DR   InterPro; IPR039979; PRPF18.
DR   PANTHER; PTHR13007; PTHR13007; 1.
DR   Pfam; PF02840; Prp18; 1.
DR   Pfam; PF08799; PRP4; 1.
DR   SMART; SM00500; SFM; 1.
DR   SUPFAM; SSF158230; SSF158230; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..342
FT                   /note="Pre-mRNA-splicing factor 18"
FT                   /id="PRO_0000324100"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99633"
SQ   SEQUENCE   342 AA;  39888 MW;  8A696DB36D163AB2 CRC64;
     MDILKSEILR KRQLVEDRNL LVENKKYFKR SELAKKEEEA YFERCGYRIQ PKEEDQKPLT
     SSNPVLELEL AEEKLPMTLS RQEVIRRLRE RGEPIRLFGE TDYDAFQRLR KIEILTPEVN
     KGLRNDLKAA LDKIDQQYLN EIVGGQEPGE EDTQNDLKVH EENTTIEELE ALGESLGKGD
     DHKDMDIITK FLKFLLGVWA KELNAREDYV KRSVQGKLNS ATQKQTESYL RPLFRKLRKR
     NLPADIKESI TDIIKFMLQR EYVKANDAYL QMAIGNAPWP IGVTMVGIHA RTGREKIFSK
     HVAHVLNDET QRKYIQGLKR LMTICQKHFP TDPSKCVEYN AL