ID   PRP18_XENLA             Reviewed;         342 AA.
AC   Q5EAV6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Pre-mRNA-splicing factor 18;
DE   AltName: Full=PRP18 homolog;
GN   Name=prpf18;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in the second step of pre-mRNA splicing.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the spliceosome. Part of a complex containing
CC       U4/U6 snRNPs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Note=Colocalizes
CC       with spliceosomal snRNPs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PRP18 family. {ECO:0000305}.
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DR   EMBL; BC090228; AAH90228.1; -; mRNA.
DR   RefSeq; NP_001089287.1; NM_001095818.1.
DR   AlphaFoldDB; Q5EAV6; -.
DR   SMR; Q5EAV6; -.
DR   BioGRID; 592116; 1.
DR   IntAct; Q5EAV6; 1.
DR   MaxQB; Q5EAV6; -.
DR   DNASU; 734335; -.
DR   GeneID; 734335; -.
DR   KEGG; xla:734335; -.
DR   CTD; 734335; -.
DR   Xenbase; XB-GENE-5838471; prpf18.L.
DR   OMA; SFAQVRW; -.
DR   OrthoDB; 1485522at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 734335; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.280.110; -; 1.
DR   InterPro; IPR004098; Prp18.
DR   InterPro; IPR014906; PRP4-like.
DR   InterPro; IPR036285; PRP4-like_sf.
DR   InterPro; IPR039979; PRPF18.
DR   PANTHER; PTHR13007; PTHR13007; 1.
DR   Pfam; PF02840; Prp18; 1.
DR   Pfam; PF08799; PRP4; 1.
DR   SMART; SM00500; SFM; 1.
DR   SUPFAM; SSF158230; SSF158230; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..342
FT                   /note="Pre-mRNA-splicing factor 18"
FT                   /id="PRO_0000324102"
SQ   SEQUENCE   342 AA;  39711 MW;  AD83E67351710CDC CRC64;
     MDILKAEIAR KRKQLEEKAL VGGEKKYFKR SELTAKEKEE YFERCGYKMQ KEEEEEKPSS
     SSNPVLELEL AEEKLPMTLS RQEVIRRLRE RGEPIRLFGE TDYETFQRLR KIEILAPEVN
     KGLRNDLKAA LDKIDQQYFN ELVAGQETTD EDTQNDLKVH EENTTIEELE VLGECLGQGD
     DNKDMDTINK VLKFLLGVWA KELNAREDYV KRSVHGKLAS ATQKQTESYL KPLFRKLRKK
     NLPADIKESI TDIIKFMLQR EYVKANDAYL QMAIGNAPWP IGVTMVGIHA RTGREKIFSK
     HVAHVLNDET QRKYIQGLKR LMTICQKYFS TDPSKCVEYN AL