ID   PRP38_SCHPO             Reviewed;         210 AA.
AC   Q9UUD2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Pre-mRNA-splicing factor 38;
GN   Name=prp38 {ECO:0000312|EMBL:CAB52035.1}; ORFNames=SPBC19C2.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAB52035.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Required for pre-mRNA splicing and maintenance of stable U6
CC       small nuclear RNA levels. Implicated in the formation of stable and
CC       biologically active snRNP structures. As part of the U4/U6.U5 tri-snRNP
CC       particle, dispensible for spliceosome assembly, but required for
CC       conformational changes, which result in U4 snRNA release and the
CC       subsequent catalytic activation of the spliceosome (By similarity).
CC       {ECO:0000250|UniProtKB:Q00723}.
CC   -!- SUBUNIT: Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex
CC       of the spliceosome. {ECO:0000250|UniProtKB:Q00723}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the PRP38 family. {ECO:0000255}.
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DR   EMBL; CU329671; CAB52035.1; -; Genomic_DNA.
DR   PIR; T39799; T39799.
DR   RefSeq; NP_595693.1; NM_001021590.2.
DR   AlphaFoldDB; Q9UUD2; -.
DR   SMR; Q9UUD2; -.
DR   BioGRID; 276981; 7.
DR   IntAct; Q9UUD2; 2.
DR   STRING; 4896.SPBC19C2.08.1; -.
DR   MaxQB; Q9UUD2; -.
DR   PaxDb; Q9UUD2; -.
DR   EnsemblFungi; SPBC19C2.08.1; SPBC19C2.08.1:pep; SPBC19C2.08.
DR   GeneID; 2540453; -.
DR   KEGG; spo:SPBC19C2.08; -.
DR   PomBase; SPBC19C2.08; prp38.
DR   VEuPathDB; FungiDB:SPBC19C2.08; -.
DR   eggNOG; KOG2889; Eukaryota.
DR   HOGENOM; CLU_039466_2_1_1; -.
DR   InParanoid; Q9UUD2; -.
DR   OMA; FICLLYK; -.
DR   PhylomeDB; Q9UUD2; -.
DR   PRO; PR:Q9UUD2; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IDA:PomBase.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; ISS:PomBase.
DR   InterPro; IPR005037; PRP38.
DR   PANTHER; PTHR23142; PTHR23142; 1.
DR   Pfam; PF03371; PRP38; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; Spliceosome.
FT   CHAIN           1..210
FT                   /note="Pre-mRNA-splicing factor 38"
FT                   /id="PRO_0000328925"
FT   REGION          181..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..197
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   210 AA;  24462 MW;  EDA154276C34929B CRC64;
     MADFLARDYR SQGEAAHEML PTFLIGKILR ERIVDSIYWK EQCFGLNACS LVDRAVRLEY
     IGGQYGNQRP TEFICLLYKL LQIAPEKEII QQYLSIPEFK YLRALAAFYV RLTWDDVEVH
     QTLEPLLRDY RKLRIRTNSE IRLTYLDEVV DDLLNAEVVC DISLPPLRSR LQLEDLDLLE
     PLSSSSDEED DDEEQISKLE SNEGAVDRNI