ID   PRP39_XENLA             Reviewed;         641 AA.
AC   Q4KLU2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Pre-mRNA-processing factor 39;
DE   AltName: Full=PRP39 homolog;
GN   Name=prpf39;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PRP39 family. {ECO:0000305}.
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DR   EMBL; BC098999; AAH98999.1; -; mRNA.
DR   RefSeq; NP_001089580.1; NM_001096111.1.
DR   AlphaFoldDB; Q4KLU2; -.
DR   SMR; Q4KLU2; -.
DR   DNASU; 734636; -.
DR   GeneID; 734636; -.
DR   KEGG; xla:734636; -.
DR   CTD; 734636; -.
DR   Xenbase; XB-GENE-994641; prpf39.1.L.
DR   OrthoDB; 887474at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 734636; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   SMART; SM00386; HAT; 6.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..641
FT                   /note="Pre-mRNA-processing factor 39"
FT                   /id="PRO_0000259651"
FT   REPEAT          50..82
FT                   /note="HAT 1"
FT   REPEAT          84..116
FT                   /note="HAT 2"
FT   REPEAT          118..150
FT                   /note="HAT 3"
FT   REPEAT          158..193
FT                   /note="HAT 4"
FT   REPEAT          304..336
FT                   /note="HAT 5"
FT   REPEAT          338..370
FT                   /note="HAT 6"
FT   REPEAT          372..407
FT                   /note="HAT 7"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..50
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   641 AA;  74562 MW;  9A845C467D66A11B CRC64;
     MEKSPEHCAE GSPSPATESA PSATEPPLPS TEPPLPSTEP PLPSTEPPLP PLPPDFEKYW
     KSVQAYPEDF NTWTYLLQYV EQENHLFAAR KAFDAFLAHY PYCYGYWKKY ADLEKKNNNI
     LEADEVYRRG IQAITLSVDL WMHYLNFLKE TLDPADPETS LTLRGTFEHA VVSAGLDFRS
     DKLWEMYINW ETEQGNLSGV TSIYSRLLGI PTQFYSLHFQ RFKEHIQGHL PREFLTSEKF
     IELRKELASM TLHGGTNDDI PSGLEEIKDP AKRTTEVENM RHRIIEVHQE IFNLNEHEVS
     KIWNFEEEIK RPYFHVKPLE KAQLNNWKEY LEFELENGSN ERIVILFERC VIACACYEEF
     WIKYAKYMEN HSVEGVRHVY NRACHVHLAK KPMVHLLWAA FEEQQGNLEE ARRILKNIET
     AIEGLAMVRL RRVNLERRHG NVKEAEHLLE EAMNKTKTSS ESSFYAIKLA RHLFKVQANV
     VKARKVLSNA IQKDKENTKL YLNLLEMEYN CDIKQNEENI LAAFDKAIKS PMSIAMRVKF
     SQRKVEFLED FGSDVNKLLD TYNEHQKLLK HQDIVKRKAE NGLEQPEAKR LHAEEVSTAA
     SVPVTTASMD ATQSGYNYGS WYQYNYPANW NFGQYYNTPS T