ID   PRP3_RAT                Reviewed;         206 AA.
AC   P04474;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Acidic proline-rich protein PRP33;
DE   AltName: Full=Proline-rich proteoglycan 1;
DE   Flags: Precursor;
GN   Name=Prpg1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Parotid gland;
RX   PubMed=6547951; DOI=10.1016/s0021-9258(18)90988-9;
RA   Ziemer M.A., Swain W.F., Rutter W.J., Clements S., Ann D.K., Carlson D.M.;
RT   "Nucleotide sequence analysis of a proline-rich protein cDNA and peptide
RT   homologies of rat and human proline-rich proteins.";
RL   J. Biol. Chem. 259:10475-10480(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-23.
RC   TISSUE=Parotid gland;
RX   PubMed=3840480; DOI=10.1016/s0021-9258(17)38745-8;
RA   Clements S., Mehansho H., Carlson D.M.;
RT   "Novel multigene families encoding highly repetitive peptide sequences.
RT   Sequence analyses of rat and mouse proline-rich protein cDNAs.";
RL   J. Biol. Chem. 260:13471-13477(1985).
CC   -!- FUNCTION: May protect teeth by binding to tannins.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; K02247; AAA41949.1; -; mRNA.
DR   EMBL; M11898; AAA41958.1; -; mRNA.
DR   PIR; A03296; PIRT3.
DR   AlphaFoldDB; P04474; -.
DR   PaxDb; P04474; -.
DR   UCSC; RGD:628796; rat.
DR   RGD; 628796; Prpg1.
DR   eggNOG; ENOG502TF4Q; Eukaryota.
DR   InParanoid; P04474; -.
DR   PRO; PR:P04474; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026086; Pro-rich.
DR   PANTHER; PTHR23203; PTHR23203; 2.
DR   Pfam; PF15240; Pro-rich; 2.
DR   SMART; SM01412; Pro-rich; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..13
FT                   /evidence="ECO:0000255"
FT   CHAIN           14..206
FT                   /note="Acidic proline-rich protein PRP33"
FT                   /id="PRO_0000022135"
FT   REPEAT          80..97
FT                   /note="1"
FT   REPEAT          98..115
FT                   /note="2"
FT   REPEAT          116..133
FT                   /note="3"
FT   REPEAT          134..152
FT                   /note="4"
FT   REPEAT          153..170
FT                   /note="5"
FT   REPEAT          171..189
FT                   /note="6"
FT   REGION          15..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..189
FT                   /note="6 X 18 AA approximate tandem repeats"
FT   COMPBIAS        39..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..71
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..188
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   206 AA;  21403 MW;  D037582CED05CE6B CRC64;
     MLVVLLTAAL LVLSSAHGSD EEVIYEDSSS QLLDVEQQNQ KHGQHHQKPP PASDENGDGD
     DSDDGDDDGS GDDGNRPERP PPHGGNHQRP PPGHHHGPPP SGGPQTSSQP GNPQGPPPQG
     GPQGPPQPGN PQGPPPQGGP QQRPPQPGKP QGPPPQGGPQ GPPQPGNPQG PPPQGGHQQR
     PPQPRKPQDP AQDATHEQPS YLWFSS