PRP45_ASHGO
ID PRP45_ASHGO Reviewed; 443 AA.
AC Q759B6;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Pre-mRNA-processing protein 45;
GN Name=PRP45; OrderedLocusNames=ADR361W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SNW family. {ECO:0000305}.
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DR EMBL; AE016817; AAS52281.1; -; Genomic_DNA.
DR RefSeq; NP_984457.1; NM_209810.1.
DR AlphaFoldDB; Q759B6; -.
DR SMR; Q759B6; -.
DR STRING; 33169.AAS52281; -.
DR EnsemblFungi; AAS52281; AAS52281; AGOS_ADR361W.
DR GeneID; 4620622; -.
DR KEGG; ago:AGOS_ADR361W; -.
DR eggNOG; KOG2441; Eukaryota.
DR HOGENOM; CLU_006601_3_1_1; -.
DR InParanoid; Q759B6; -.
DR OMA; NGFTIAL; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:EnsemblFungi.
DR GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IEA:EnsemblFungi.
DR InterPro; IPR017862; SKI-int_prot_SKIP.
DR InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR PANTHER; PTHR12096; PTHR12096; 1.
DR Pfam; PF02731; SKIP_SNW; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT CHAIN 1..443
FT /note="Pre-mRNA-processing protein 45"
FT /id="PRO_0000084814"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 443 AA; 50089 MW; F2546D1D176E6CFA CRC64;
MNSAPFSTLL PPPKKESSPT VASAHQSPEN QGDEPVAGIV FDSLQPDGIP NVSFQDFIPI
RQRDFNMEIP LPSKQDIEQT FQRTKAYFDK LLNNKPATNS RPSTDARSGK GNYIEYKTTD
ALTNKSTSRI IKIVDHVADP LQPSQIKRKK VVAPPTDEPV APILHSATEK LTKEQREQWR
IPSAVSNWKN PNGYAIDLEK RIAIDGRYNR EGTAIPAVNE KLLELTNALE EAESKAREEV
RNRAEARKQE AEQQVRLKED KLRELAQRSR EERQRKRRQP IDHEEYDESA IIRQTERNEK
RDQMKNDMRL SKLSTADRLR VLAHAQGRDV SEKIILGAAK PSEVPDVHYD SRLLTKGAGT
AVPGAPEQVY DGPLFAQNAM DRLYKPARFT GPENDALDIL SKMTSEQRFE DQDPGTSVDQ
QQTSPGMQKS DAKQDSEHDL KRT
