ID   PRP45_ASPFU             Reviewed;         579 AA.
AC   Q4WEH7;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Pre-mRNA-processing protein 45;
GN   Name=prp45; ORFNames=AFUA_5G03050;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNW family. {ECO:0000305}.
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DR   EMBL; AAHF01000011; EAL86000.1; -; Genomic_DNA.
DR   RefSeq; XP_748038.1; XM_742945.1.
DR   AlphaFoldDB; Q4WEH7; -.
DR   SMR; Q4WEH7; -.
DR   STRING; 746128.CADAFUBP00005047; -.
DR   EnsemblFungi; EAL86000; EAL86000; AFUA_5G03050.
DR   GeneID; 3505594; -.
DR   KEGG; afm:AFUA_5G03050; -.
DR   VEuPathDB; FungiDB:Afu5g03050; -.
DR   eggNOG; KOG2441; Eukaryota.
DR   HOGENOM; CLU_006601_2_0_1; -.
DR   InParanoid; Q4WEH7; -.
DR   OMA; WRDSNTL; -.
DR   OrthoDB; 1455730at2759; -.
DR   Proteomes; UP000002530; Chromosome 5.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   InterPro; IPR017862; SKI-int_prot_SKIP.
DR   InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR   PANTHER; PTHR12096; PTHR12096; 1.
DR   Pfam; PF02731; SKIP_SNW; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..579
FT                   /note="Pre-mRNA-processing protein 45"
FT                   /id="PRO_0000084815"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          343..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..378
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..414
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        560..579
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  65071 MW;  E004C828CBDBC3CE CRC64;
     MTSVAEGLFK SLPKPKYTGE DEEVPQHAQP RGPRIVGADQ IDQSQIVLRR TGPPPYGNRA
     GWRPRAAEDF GDGGAFPEIL VAQYPLDMGR KGTATTSNAL AVQVDAEGKV KYDAIARRGH
     SENRIVHASF KDLIPLRQRV DMGEISLDRP SEEEVQAQME KTKNALASLV EGAVAAQKPK
     NVKGGRRAEP TFVRYTPANQ MGDTTRKNDR IMKIVERQQD PMEPPKFKHK KIPRGPPSPP
     PPIMHSPPRK LTAEDQEAWR IPPPVSNWKN PKGYTVPLDK RLAADGRGLQ DVTINDKFAQ
     FAEALFTADR HAREEVRLRA QMQQKLAEKE KAQKEEHLRA LAQKAREERA ASNRRDSRAR
     SHTRSASRSP SAYSRSATPS DDEEAARERE RIRRERRQDA ERQLRQSRMG TERRIQMMAR
     EQNRDISEKV ALGLAKPTQT SESMWDSRLF NQTSGLQSGF NEDNPYDKPL FAAQDAINSI
     YRPRAQLDVD DEEGAEGEMS KIQKTNRFEV LGKAKEGFRG AAEAEARDGP VQFEKDTTDP
     FGIDSMIADV TGGAGQKRYG IQEVEREDRG SKRARVDDD