PRP45_CANAL
ID PRP45_CANAL Reviewed; 286 AA.
AC Q5AC37; A0A1D8PPV8;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Pre-mRNA-processing protein 45;
GN Name=PRP45; OrderedLocusNames=CAALFM_C602440CA;
GN ORFNames=CaO19.12959, CaO19.5513;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SNW family. {ECO:0000305}.
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DR EMBL; CP017628; AOW30177.1; -; Genomic_DNA.
DR RefSeq; XP_719078.1; XM_713985.1.
DR AlphaFoldDB; Q5AC37; -.
DR SMR; Q5AC37; -.
DR STRING; 237561.Q5AC37; -.
DR GeneID; 3639166; -.
DR KEGG; cal:CAALFM_C602440CA; -.
DR CGD; CAL0000177849; PRP45.
DR VEuPathDB; FungiDB:C6_02440C_A; -.
DR eggNOG; KOG2441; Eukaryota.
DR HOGENOM; CLU_085411_0_0_1; -.
DR InParanoid; Q5AC37; -.
DR OrthoDB; 1455730at2759; -.
DR PRO; PR:Q5AC37; -.
DR Proteomes; UP000000559; Chromosome 6.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR InterPro; IPR017862; SKI-int_prot_SKIP.
DR InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR PANTHER; PTHR12096; PTHR12096; 1.
DR Pfam; PF02731; SKIP_SNW; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT CHAIN 1..286
FT /note="Pre-mRNA-processing protein 45"
FT /id="PRO_0000084816"
FT REGION 111..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 286 AA; 33200 MW; EE23347794848E77 CRC64;
MASCNLLVIQ TTSIIMFSSL LSRPVNSSYD PSYHFSPVTR EIKNDPTSNG VVSTTKNATP
LAPSKYDTTI PLKKRYPNLV HNFPKPELDE NVILETKKII DSILNPSDEP TNDINYIKYE
NPNPNPNPNP NPNQEQQQQS SSSSSKIIQI KQFQEDPMLP PKFKLRKNRH ERIIEDVTFV
KDLKTKKLTK EDREFWNIPA AVSNWKNSQG FTIGLDKRMI GREHVPIEMN IEKFNDLSTA
LSDADLQARE DLKQRNEIRQ QKQLQEKRLR DEKIKEIANR SKRRRY
