ID   PRP45_CRYNB             Reviewed;         594 AA.
AC   P0CR57; Q55JA7; Q5KCF5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Pre-mRNA-processing protein 45;
GN   Name=PRP45; OrderedLocusNames=CNBL0780;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNW family. {ECO:0000305}.
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DR   EMBL; AAEY01000056; EAL17816.1; -; Genomic_DNA.
DR   RefSeq; XP_772463.1; XM_767370.1.
DR   AlphaFoldDB; P0CR57; -.
DR   SMR; P0CR57; -.
DR   PRIDE; P0CR57; -.
DR   EnsemblFungi; EAL17816; EAL17816; CNBL0780.
DR   GeneID; 4939127; -.
DR   KEGG; cnb:CNBL0780; -.
DR   VEuPathDB; FungiDB:CNBL0780; -.
DR   HOGENOM; CLU_006601_2_0_1; -.
DR   Proteomes; UP000001435; Chromosome 12.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   InterPro; IPR017862; SKI-int_prot_SKIP.
DR   InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR   PANTHER; PTHR12096; PTHR12096; 1.
DR   Pfam; PF02731; SKIP_SNW; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Spliceosome.
FT   CHAIN           1..594
FT                   /note="Pre-mRNA-processing protein 45"
FT                   /id="PRO_0000410290"
FT   REGION          36..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          498..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          566..594
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..397
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..421
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..523
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..594
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   594 AA;  65795 MW;  E6485319F4199FD9 CRC64;
     MIHSHNNNLS FCSQLITVRK MAALTRALPA PLHTSTTEYE EVPAPLPATP GPQLPKYGQR
     KGWKPKTAAD FNGGGAYPEC HVAQYPLDMG KKNKGQGSTL ALQVDQDGLV RYDAIAQHGR
     APGSRVQSSF KDLVPLANRT DVTESERQME RPDDLSVAET AERTRLALER ITHGKIKAAQ
     PKHVPKTNSD ATYIRYTPAN QSADEGKQRI IKMTEVQEDP LEPPRFKHKK IPRGPAEPPP
     PVLQSPPRAA TAQDQKDWMI PPCISNWKNN KGYTIPLDKR LAADGRGLQD VHINDNFAKF
     SESLYIADRH IREEVRARAQ LQQLLAQKQK TSKEEELRLL AQRAREDRSG LSSSVSGSVA
     AASASRLPAE TGINLGGYGS ESGSEEESDE EEEDEEAIRE RNIVREEKRR EREKEMRMSN
     MGSEMRAKML AKEANRDISE KIALGLAKPS ASKETLLDSR LFNREALSTG FASEDSYNLY
     DKPLFAGSSA AAAIYRPAGS SRNDESFGGG TEEGIKEEMS KDRFQLGNAT RGFEGAEGVE
     AREGPVQFEK DTIVALDGSA DPFGVEQFMD AARRGGKRTA EDRDEERRKR ARDE