PRP45_CRYNJ
ID PRP45_CRYNJ Reviewed; 594 AA.
AC P0CR56; Q55JA7; Q5KCF5;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 41.
DE RecName: Full=Pre-mRNA-processing protein 45;
GN Name=PRP45; OrderedLocusNames=CNH00830;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SNW family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017348; AAW44969.1; -; Genomic_DNA.
DR RefSeq; XP_572276.1; XM_572276.1.
DR AlphaFoldDB; P0CR56; -.
DR SMR; P0CR56; -.
DR STRING; 5207.AAW44969; -.
DR PaxDb; P0CR56; -.
DR EnsemblFungi; AAW44969; AAW44969; CNH00830.
DR GeneID; 3259100; -.
DR KEGG; cne:CNH00830; -.
DR eggNOG; KOG2441; Eukaryota.
DR HOGENOM; CLU_006601_2_0_1; -.
DR InParanoid; P0CR56; -.
DR OMA; WRDSNTL; -.
DR OrthoDB; 1455730at2759; -.
DR Proteomes; UP000002149; Chromosome 8.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR InterPro; IPR017862; SKI-int_prot_SKIP.
DR InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR PANTHER; PTHR12096; PTHR12096; 1.
DR Pfam; PF02731; SKIP_SNW; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT CHAIN 1..594
FT /note="Pre-mRNA-processing protein 45"
FT /id="PRO_0000084818"
FT REGION 34..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..397
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 65797 MW; E141F12299EAE6A9 CRC64;
MIHSHNNNLS FCSQLITVRK MAALTRALPA PLHTSTTEYE EAPAPLPTTP GPQLPKYGQR
KGWKPKTAAD FNGGGAYPEC HVAQYPLDMG KKNKGQGSTL ALQVDQDGLV RYDAIAQHGR
APGSRVQSSF KDLVPLANRT DVTESERQME RPDDLSVAET AERTRLALER ITHGKIKAAQ
PKHVPKTNSD ATYIRYTPAN QSADEGKQRI IKMTEVQEDP LEPPRFKHKK IPRGPAEPPP
PVLQSPPRAA TAQDQKDWMI PPCISNWKNN KGYTIPLDKR LAADGRGLQD VHINDNFAKF
SESLYIADRH IREEVRARAQ LQQLLAQKQK TSKEEELRLL AQRAREDRSG LSSSVSGSVA
AASASRLPAE TGINLGGYGS ESGSEEESDE EEEDEEAIRE RNIVREEKRR EREKEMRMSN
MGSEMRAKML AKEANRDISE KIALGLAKPS ASKETLLDSR LFNREALSTG FASEDSYNLY
DKPLFAGSSA AAAIYRPAGS SRNDESFGGG TEEGIKEEMS KDRFQLGNAT RGFEGAEGVE
AREGPVQFEK DTIVALDGSA DPFGVEQFMD AARRGGKRTA EDRDEERRKR ARDE