ID   PRP45_DEBHA             Reviewed;         341 AA.
AC   Q6BV91;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Pre-mRNA-processing protein 45;
GN   Name=PRP45; OrderedLocusNames=DEHA2C04444g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNW family. {ECO:0000305}.
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DR   EMBL; CR382135; CAG85924.1; -; Genomic_DNA.
DR   RefSeq; XP_457878.1; XM_457878.1.
DR   AlphaFoldDB; Q6BV91; -.
DR   SMR; Q6BV91; -.
DR   STRING; 4959.XP_457878.1; -.
DR   PRIDE; Q6BV91; -.
DR   EnsemblFungi; CAG85924; CAG85924; DEHA2C04444g.
DR   GeneID; 2900690; -.
DR   KEGG; dha:DEHA2C04444g; -.
DR   VEuPathDB; FungiDB:DEHA2C04444g; -.
DR   eggNOG; KOG2441; Eukaryota.
DR   HOGENOM; CLU_085411_0_0_1; -.
DR   InParanoid; Q6BV91; -.
DR   OMA; HHFPRYT; -.
DR   OrthoDB; 1455730at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   InterPro; IPR017862; SKI-int_prot_SKIP.
DR   InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR   PANTHER; PTHR12096; PTHR12096; 1.
DR   Pfam; PF02731; SKIP_SNW; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..341
FT                   /note="Pre-mRNA-processing protein 45"
FT                   /id="PRO_0000084819"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          302..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   341 AA;  39034 MW;  789F3F14E0EDF22F CRC64;
     MFSSLLPKPK YSSHEPTSRI KLKKVRAHEK SNQLVKLPEN KSDIKVTHNP SNSESTISQL
     HLNPDGTLNY NLTIASSNSN SRKVQSSYED TIPLKVKFPN LKHHFPRYTV ETCPDDSLKE
     CVEDTKAAIN KMINEKMGVD EKTNNKKDDV TYIKYTSNNL VNDPEGSDDE RGRERIIQIR
     NYQEDPMLPP KFKLRKNRHK NPSPPPPLLK SSNNEQTSKL TKEDQAKWQI PSAISNWKNN
     QGFTISLDKR MVAANGGSEL ATNDVNLEKF GELSQALENA DKQAREEIKI RSEMLKQLAI
     KEQHEKENKL KELADIARSK KLNNKRPPNG DYDDVKKKTK Y