ID   PRP45_KLULA             Reviewed;         430 AA.
AC   Q6CLJ7;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Pre-mRNA-processing protein 45;
GN   Name=PRP45; OrderedLocusNames=KLLA0F02475g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNW family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG97899.1; -; Genomic_DNA.
DR   RefSeq; XP_455192.1; XM_455192.1.
DR   AlphaFoldDB; Q6CLJ7; -.
DR   STRING; 28985.XP_455192.1; -.
DR   PRIDE; Q6CLJ7; -.
DR   EnsemblFungi; CAG97899; CAG97899; KLLA0_F02475g.
DR   GeneID; 2894911; -.
DR   KEGG; kla:KLLA0_F02475g; -.
DR   eggNOG; KOG2441; Eukaryota.
DR   HOGENOM; CLU_006601_3_1_1; -.
DR   InParanoid; Q6CLJ7; -.
DR   OMA; NGFTIAL; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   InterPro; IPR017862; SKI-int_prot_SKIP.
DR   InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR   PANTHER; PTHR12096; PTHR12096; 1.
DR   Pfam; PF02731; SKIP_SNW; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..430
FT                   /note="Pre-mRNA-processing protein 45"
FT                   /id="PRO_0000084821"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..430
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   430 AA;  49358 MW;  F29600F082EEEED4 CRC64;
     MSFRTLSSLL PSPQNSEVSE SSAFSRQSKE NIKDTIILDK LRPENLPVAS ISDFVPLRQR
     DISLEAPFPS TSQINQTYVK TKAFLDSLLT KKSSLQLSSI ANKDIVKREA ISSVKSGTQR
     SVKVIEHKKD PLQPVTHRKR KVVVPSEEIQ APILHKSDDP SIKPTKEELD KWRIPSAISN
     WKNPNGFAIS LDNRVAIESI KTDCPDNDKK DNFLLLSEAL DEAEREARQR INIKQEAYKE
     LEKEETLKKE QRLRHLAERA RQDRENRRQY ENEDHYVREM ERNQRRRAER ELERSNKMST
     AEKLRRLAYQ QGRDVSDKVV LNAAKATETP DLQYDSRLFK KAASSVASSS NQIFDHPLFN
     NSQIDNIYRP TTGSNLENED IVDRLSNKKG RTGPVEFSAA DDGKNAEQNE EDNEHAREYG
     LQVRKKPHTS