ID   PRP45_YARLI             Reviewed;         568 AA.
AC   Q6CC77;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Pre-mRNA-processing protein 45;
GN   Name=PRP45; OrderedLocusNames=YALI0C11715g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNW family. {ECO:0000305}.
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DR   EMBL; CR382129; CAG82045.1; -; Genomic_DNA.
DR   RefSeq; XP_501735.1; XM_501735.1.
DR   AlphaFoldDB; Q6CC77; -.
DR   SMR; Q6CC77; -.
DR   STRING; 4952.CAG82045; -.
DR   PRIDE; Q6CC77; -.
DR   EnsemblFungi; CAG82045; CAG82045; YALI0_C11715g.
DR   GeneID; 2909266; -.
DR   KEGG; yli:YALI0C11715g; -.
DR   VEuPathDB; FungiDB:YALI0_C11715g; -.
DR   HOGENOM; CLU_006601_2_0_1; -.
DR   InParanoid; Q6CC77; -.
DR   OMA; WRDSNTL; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   InterPro; IPR017862; SKI-int_prot_SKIP.
DR   InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR   PANTHER; PTHR12096; PTHR12096; 1.
DR   Pfam; PF02731; SKIP_SNW; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..568
FT                   /note="Pre-mRNA-processing protein 45"
FT                   /id="PRO_0000084824"
FT   REGION          199..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          545..568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   568 AA;  63594 MW;  5DABF3C2CB5AA976 CRC64;
     MTSITALLPA PRYPTPGPKM SIFTTNAVSM AKNDSVPKYG SRTDWKPTSQ ADFNDGGAYP
     EIHIAQYPRN MGKPGSVSSN AITLKMDASG SADYSLIATQ GHAADRHVQT SYDSLIPLRE
     RIDAGTVSLE KPGEEAEQST ALATQAAFDK RLAANDKSGT KNKSDPQYIR YTANSMMGTE
     GGESQKIIKM VDLPQDPLEP PKFKHTKVPG RPASPPAPIL RSPPRKLTAQ DQKDWAIPST
     VSNWKNQKGF TISLDKRMAA DGRGLEDVKV NENFAKFSEV LNQNEKTMRD DIGKRREMQQ
     RVAERQAQEQ EEKLRELARR ARQEREVGDE SKGKEKEADG EDDRGRSRER LRSVSRDGDS
     DRSLSRSLSA SDRSYSRSRS PYESRSRGRS YSRSRSPESR FRGRSDSRSR SPGYELERAA
     KKRKTERLER KREAERDLRL SKMGTQQKIK QLAKENSRDI SERVALGAAQ PQKLAGEAQF
     DSRLFSKSGS LQRGFNEDQY YDKSLFSAQE AVQSIYRPSA SGDSVAEDTI DRLETEKRFD
     VLGKAGKGFE GADGEERDGP VRFVRDEE