ID   PRP46_ASPFU             Reviewed;         453 AA.
AC   Q4WT34;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Pre-mRNA-splicing factor prp46;
DE   AltName: Full=Pre-mRNA-processing protein 46;
GN   Name=prp46; ORFNames=AFUA_1G10710;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and required for cell cycle
CC       progression at G2/M. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family. {ECO:0000305}.
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DR   EMBL; AAHF01000004; EAL90398.1; -; Genomic_DNA.
DR   RefSeq; XP_752436.1; XM_747343.1.
DR   AlphaFoldDB; Q4WT34; -.
DR   SMR; Q4WT34; -.
DR   STRING; 746128.CADAFUBP00000994; -.
DR   EnsemblFungi; EAL90398; EAL90398; AFUA_1G10710.
DR   GeneID; 3510553; -.
DR   KEGG; afm:AFUA_1G10710; -.
DR   VEuPathDB; FungiDB:Afu1g10710; -.
DR   eggNOG; KOG0285; Eukaryota.
DR   HOGENOM; CLU_000288_72_2_1; -.
DR   InParanoid; Q4WT34; -.
DR   OMA; HPLEWKP; -.
DR   OrthoDB; 1157847at2759; -.
DR   Proteomes; UP000002530; Chromosome 1.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR045241; Prp46/PLRG1-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19923; PTHR19923; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Repeat; Spliceosome; WD repeat.
FT   CHAIN           1..453
FT                   /note="Pre-mRNA-splicing factor prp46"
FT                   /id="PRO_0000051160"
FT   REPEAT          142..181
FT                   /note="WD 1"
FT   REPEAT          184..223
FT                   /note="WD 2"
FT   REPEAT          226..265
FT                   /note="WD 3"
FT   REPEAT          268..309
FT                   /note="WD 4"
FT   REPEAT          311..350
FT                   /note="WD 5"
FT   REPEAT          351..389
FT                   /note="WD 6"
FT   REPEAT          400..439
FT                   /note="WD 7"
FT   REGION          62..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          432..453
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  49448 MW;  464FEAE5FCCE007B CRC64;
     MDVFPSTTPD EAVRKSAKRT AELFGSEYLL VTPSVADGSI GLSYRKKAEY SDVKELPPAL
     AEKQAKAAAA GRAKRPKIQP QTKPQADGSG ASMSLVKRAA GPAAGGVGGE GQPKSLIQRP
     SATRQQRPDW HPPWKLMRVI SGHLGWVRSL AVEPNNEWFA SGAGDRTIKI WNLATGALRL
     TLTGHISTVR GLAVSPRHPY LFSCGEDKMV KCWDLETNKV IRHYHGHLSG VYTLALHPRL
     DLLVTGGRDG VARVWDMRTR SNIHVLSGHK GTVADLKCQE ADPQIITGSL DATVRLWDLA
     AGKTMGVLTH HKKGVRNLAI HPREFTFASA STGSIKQWKC PEGDFMQNFE GHNAVINSLA
     VNEDNVLFSG GDNGSMCFWD WKTGYKFQSI DTMAQPGSLD AEAGIMSATF DRTGLRLITG
     EADKTIKVWK PDDEATPESH PVTWAPTLGR QRY