ID   PRP46_CANAL             Reviewed;         389 AA.
AC   Q5A7Q3; A0A1D8PIY6;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Pre-mRNA-splicing factor PRP46;
DE   AltName: Full=Pre-mRNA-processing protein 46;
GN   Name=PRP46; OrderedLocusNames=CAALFM_C300500CA;
GN   ORFNames=CaO19.12868, CaO19.5413;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and required for cell cycle
CC       progression at G2/M. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP017625; AOW28100.1; -; Genomic_DNA.
DR   RefSeq; XP_717785.1; XM_712692.1.
DR   AlphaFoldDB; Q5A7Q3; -.
DR   SMR; Q5A7Q3; -.
DR   STRING; 237561.Q5A7Q3; -.
DR   GeneID; 3640515; -.
DR   KEGG; cal:CAALFM_C300500CA; -.
DR   CGD; CAL0000199442; orf19.12868.
DR   VEuPathDB; FungiDB:C3_00500C_A; -.
DR   eggNOG; KOG0285; Eukaryota.
DR   HOGENOM; CLU_000288_72_0_1; -.
DR   InParanoid; Q5A7Q3; -.
DR   OMA; DDHSVKC; -.
DR   OrthoDB; 1157847at2759; -.
DR   PRO; PR:Q5A7Q3; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR045241; Prp46/PLRG1-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19923; PTHR19923; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Repeat; Spliceosome; WD repeat.
FT   CHAIN           1..389
FT                   /note="Pre-mRNA-splicing factor PRP46"
FT                   /id="PRO_0000051161"
FT   REPEAT          83..123
FT                   /note="WD 1"
FT   REPEAT          126..165
FT                   /note="WD 2"
FT   REPEAT          173..212
FT                   /note="WD 3"
FT   REPEAT          215..254
FT                   /note="WD 4"
FT   REPEAT          257..298
FT                   /note="WD 5"
FT   REPEAT          308..347
FT                   /note="WD 6"
FT   REPEAT          356..389
FT                   /note="WD 7"
SQ   SEQUENCE   389 AA;  43262 MW;  878C59134626C3CB CRC64;
     MSVTATSHDI LKSIDDSILP PEDTLSEAMY NNVKLDHYFN KLPKSSEENN INDQTNQLIV
     SAAPESEDSP AAEWKLLRTL AGAHQGWIRA IALDEITNKW YVTGSADSTI KIWDFENNSL
     KAVLTGHVLG IRSLCISKRH PYLFSGGEDK SLRCWDLERS NSDAGCQIRS YHGHLGGVYS
     IGLHPELDVL FSGGKDCVVR VWDIRSRVEA MTLLGHTNDI TSIETDYNDP QVITSSMDGT
     IRLWDLRKSK TELLITNHSK SIRSMKSHPK EATFVSGDSN GEIKQWLLPK GELLNEFGTS
     QLSPNQRDNS RIINTLAINP VTNTLFSGYD DGKLEFYNYT TGNLQQSGQS PSLAGPEQSA
     IYASTFDMSG LRLLTCHGDK SIRIWGTSY