ID   PRP46_CANGA             Reviewed;         427 AA.
AC   Q6FJZ9;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Pre-mRNA-splicing factor PRP46;
DE   AltName: Full=Pre-mRNA-processing protein 46;
GN   Name=PRP46; OrderedLocusNames=CAGL0M02277g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and required for cell cycle
CC       progression at G2/M. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62421.1; -; Genomic_DNA.
DR   RefSeq; XP_449445.1; XM_449445.1.
DR   AlphaFoldDB; Q6FJZ9; -.
DR   SMR; Q6FJZ9; -.
DR   STRING; 5478.XP_449445.1; -.
DR   EnsemblFungi; CAG62421; CAG62421; CAGL0M02277g.
DR   GeneID; 2891771; -.
DR   KEGG; cgr:CAGL0M02277g; -.
DR   CGD; CAL0136351; CAGL0M02277g.
DR   VEuPathDB; FungiDB:CAGL0M02277g; -.
DR   eggNOG; KOG0285; Eukaryota.
DR   HOGENOM; CLU_000288_72_0_1; -.
DR   InParanoid; Q6FJZ9; -.
DR   OMA; HPLEWKP; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR045241; Prp46/PLRG1-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19923; PTHR19923; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Repeat; Spliceosome; WD repeat.
FT   CHAIN           1..427
FT                   /note="Pre-mRNA-splicing factor PRP46"
FT                   /id="PRO_0000051162"
FT   REPEAT          113..153
FT                   /note="WD 1"
FT   REPEAT          156..195
FT                   /note="WD 2"
FT   REPEAT          198..237
FT                   /note="WD 3"
FT   REPEAT          240..281
FT                   /note="WD 4"
FT   REPEAT          283..322
FT                   /note="WD 5"
FT   REPEAT          324..362
FT                   /note="WD 6"
FT   REPEAT          373..412
FT                   /note="WD 7"
FT   REGION          404..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..427
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   427 AA;  48069 MW;  0662CE734354AEEC CRC64;
     MSIGDELVDA DEVYRQARWK NQFEVLSKLP RVLQERVDAQ KPVIEASGNS ATPSNASRAL
     VRHQQNPGDV GLVLNKKFAD EQGHESVIER HDKLLNQTPR WHAPWHLTRV IHGHHGWVRC
     IAMDKVDNEW FATGSNDKTI KIWNLASGKL KVTLKAHDMT VRDLAISNRH PYMFSVSEDK
     TVKCWDLEKN TAIRNYHGHL SGVHTVDIHP TVDVVVTAGR DSVVKVWDIR TRLPVMTLPG
     HKGPITKVRC LPVDPQVISS SVDASIRLWD LVAGKSMKVL THHQRTVRDI SVHPSEFSFA
     SACTNDIRSW LLPKGELLTN FVSQDLDVIN TVSINQDDVL FAGSDNGSLT FFDYKSGHKY
     QTFKTKEAPG SPESERGILS STFDGTGLRL LTGETDRTIK IWKQDETASQ DTHPNLPWNP
     KLDSQRL