PRP46_DEBHA
ID PRP46_DEBHA Reviewed; 417 AA.
AC Q6BU94;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Pre-mRNA-splicing factor PRP46;
DE AltName: Full=Pre-mRNA-processing protein 46;
GN Name=PRP46; OrderedLocusNames=DEHA2C12650g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in pre-mRNA splicing and required for cell cycle
CC progression at G2/M. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family. {ECO:0000305}.
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DR EMBL; CR382135; CAG86301.2; -; Genomic_DNA.
DR RefSeq; XP_458225.2; XM_458225.1.
DR AlphaFoldDB; Q6BU94; -.
DR SMR; Q6BU94; -.
DR STRING; 4959.XP_458225.2; -.
DR EnsemblFungi; CAG86301; CAG86301; DEHA2C12650g.
DR GeneID; 2899988; -.
DR KEGG; dha:DEHA2C12650g; -.
DR VEuPathDB; FungiDB:DEHA2C12650g; -.
DR eggNOG; KOG0285; Eukaryota.
DR HOGENOM; CLU_000288_72_0_1; -.
DR InParanoid; Q6BU94; -.
DR OMA; DDHSVKC; -.
DR OrthoDB; 1157847at2759; -.
DR Proteomes; UP000000599; Chromosome C.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR045241; Prp46/PLRG1-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19923; PTHR19923; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Repeat; Spliceosome; WD repeat.
FT CHAIN 1..417
FT /note="Pre-mRNA-splicing factor PRP46"
FT /id="PRO_0000051164"
FT REPEAT 119..159
FT /note="WD 1"
FT REPEAT 162..201
FT /note="WD 2"
FT REPEAT 209..248
FT /note="WD 3"
FT REPEAT 251..290
FT /note="WD 4"
FT REPEAT 293..334
FT /note="WD 5"
FT REPEAT 337..376
FT /note="WD 6"
FT REPEAT 385..417
FT /note="WD 7"
SQ SEQUENCE 417 AA; 46629 MW; D016DE64BB8328CE CRC64;
MNFNIIIKII CENIQLAPII NMVSYKELFN INDTDLIVPS DTLSEAVYDN SKLDYIFQNV
NRRNRDEVED ESINIQTQLP KQQNQQISKD MSEVGSKQVS EIRPDSDSRW KLLRVMAGAH
QGWVRSCTVD PVTNKWFVTG SSDSTIKIWD LASSNLKATI TGHIMGVRSL AVSSRYPYLF
SGSEDKTVKC WDLERTNSSS GCQIRNYHGH VGGIYAMALH PELDLLFTGG RDSVIRVWDL
RSRTEIMVLS GHRSDITSIA SQIGDPQIIT SSMDATIRLW DIRKATTQLA LTHHSKSIRS
MAMHPQEMTM CSGDTSGNLK EWLLPGGELL NEFGHSGENK IINTLSINPS NNTLFSGYDD
GRMEFYDYVS GDLLQSDATT PVTGSTESAI YASTFDMSGL RLITCEGDKS IKIWGEE
