ID   PRP46_KLULA             Reviewed;         434 AA.
AC   Q6CKE8;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Pre-mRNA-splicing factor PRP46;
DE   AltName: Full=Pre-mRNA-processing protein 46;
GN   Name=PRP46; OrderedLocusNames=KLLA0F11231g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and required for cell cycle
CC       progression at G2/M. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98299.1; -; Genomic_DNA.
DR   RefSeq; XP_455591.1; XM_455591.1.
DR   AlphaFoldDB; Q6CKE8; -.
DR   SMR; Q6CKE8; -.
DR   STRING; 28985.XP_455591.1; -.
DR   EnsemblFungi; CAG98299; CAG98299; KLLA0_F11231g.
DR   GeneID; 2895081; -.
DR   KEGG; kla:KLLA0_F11231g; -.
DR   eggNOG; KOG0285; Eukaryota.
DR   HOGENOM; CLU_000288_72_0_1; -.
DR   InParanoid; Q6CKE8; -.
DR   OMA; HPLEWKP; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR045241; Prp46/PLRG1-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19923; PTHR19923; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Repeat; Spliceosome; WD repeat.
FT   CHAIN           1..434
FT                   /note="Pre-mRNA-splicing factor PRP46"
FT                   /id="PRO_0000051166"
FT   REPEAT          120..160
FT                   /note="WD 1"
FT   REPEAT          163..202
FT                   /note="WD 2"
FT   REPEAT          205..244
FT                   /note="WD 3"
FT   REPEAT          247..288
FT                   /note="WD 4"
FT   REPEAT          290..329
FT                   /note="WD 5"
FT   REPEAT          331..369
FT                   /note="WD 6"
FT   REPEAT          380..419
FT                   /note="WD 7"
SQ   SEQUENCE   434 AA;  48938 MW;  59CE3C5419DE759E CRC64;
     MNTSSRSSEP SKVADDVYVQ TRWNNEFKHA DYLPESLQKC LDQEKTVLER YSELVEVSKT
     VANESSQALV KHTTKPGDQL VRRVFQQPHQ QISLMERYEK TRSYKPQWHA PWKLSKVING
     HTGWVRCVCV DPVDNEWFAT GSNDTTIKIW DLAAGKLKIT LIGHVMSVRD IAISKRHPYM
     FSASEDKLVK CWDLERNTAI RDFHGHLSGV HTVDVHPSLD IIATAGRDAV VRLWDIRSRS
     EIMVLPGHKS PINKVKCLPV DPQIISCSGD ATVRLWDIIA GKASKVLTHH SRNIRDLTLH
     PAEFSFASVS TNDVRSWKLP EGQLLTNFQS QNTGILNTVS INHDNVLLAG GDDGTLCFYD
     YKTGHKYQSM MTTEVAGSLE SERSILCSTF DVTGTRLITG EGDKSIKIWK QVPDATEDTF
     PGLPWNPTLI SQRF