PRP6_PONAB
ID PRP6_PONAB Reviewed; 941 AA.
AC Q5RCC2;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Pre-mRNA-processing factor 6;
DE AltName: Full=PRP6 homolog;
DE AltName: Full=U5 snRNP-associated 102 kDa protein;
DE Short=U5-102 kDa protein;
GN Name=PRPF6;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pre-mRNA splicing as component of the U4/U6-U5
CC tri-snRNP complex, one of the building blocks of the spliceosome.
CC Enhances dihydrotestosterone-induced transactivation activity of AR, as
CC well as dexamethasone-induced transactivation activity of NR3C1, but
CC does not affect estrogen-induced transactivation.
CC {ECO:0000250|UniProtKB:O94906}.
CC -!- SUBUNIT: Identified in the spliceosome B complex. Identified in the
CC spliceosome C complex. Associates with the U5 snRNP particle. Component
CC of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs
CC and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A,
CC SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, LSm
CC proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Interacts with
CC AR and NR3C1, but not ESR1, independently of the presence of hormones.
CC Interacts with USH1G. {ECO:0000250|UniProtKB:O94906}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000250|UniProtKB:O94906}. Nucleus speckle
CC {ECO:0000250|UniProtKB:O94906}. Note=Localized in splicing speckles.
CC {ECO:0000250|UniProtKB:O94906}.
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DR EMBL; CR858352; CAH90585.1; -; mRNA.
DR RefSeq; NP_001125315.1; NM_001131843.1.
DR AlphaFoldDB; Q5RCC2; -.
DR SMR; Q5RCC2; -.
DR STRING; 9601.ENSPPYP00000012574; -.
DR GeneID; 100172214; -.
DR KEGG; pon:100172214; -.
DR CTD; 24148; -.
DR eggNOG; KOG0495; Eukaryota.
DR InParanoid; Q5RCC2; -.
DR OrthoDB; 335779at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 4.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR010491; PRP1_N.
DR InterPro; IPR027108; Prp6/Prp1/STA1.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11246; PTHR11246; 1.
DR PANTHER; PTHR11246:SF1; PTHR11246:SF1; 1.
DR Pfam; PF06424; PRP1_N; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00386; HAT; 13.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF48452; SSF48452; 4.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Spliceosome.
FT CHAIN 1..941
FT /note="Pre-mRNA-processing factor 6"
FT /id="PRO_0000413095"
FT REPEAT 384..416
FT /note="HAT 1"
FT REPEAT 418..444
FT /note="HAT 2"
FT REPEAT 445..476
FT /note="HAT 3"
FT REPEAT 554..586
FT /note="HAT 4"
FT REPEAT 588..620
FT /note="HAT 5"
FT REPEAT 622..654
FT /note="HAT 6"
FT REPEAT 689..721
FT /note="HAT 7"
FT REPEAT 723..755
FT /note="HAT 8"
FT REPEAT 855..887
FT /note="HAT 9"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94906"
FT MOD_RES 180
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O94906"
FT MOD_RES 266
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O94906"
FT MOD_RES 275
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O94906"
FT MOD_RES 279
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94906"
SQ SEQUENCE 941 AA; 107002 MW; FEC036C586E81823 CRC64;
MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP PGKRTVGDQM
KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE ADAIYAALDK RMDERRKERR
EQREKEEIEK YRMERPKIQQ QFSDLKRKLA EVTEEEWLSI PEVGDARNKR QRNPRYEKLT
PVPDSFFAKH LQTGENHTSV DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM
RKIGQARNTL MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS
VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA RLQPGDTAKA
VVAQAVRHLP QFVRIYIRAA ELETDIRAKK RVLRKALEHV PNSVRLWKAA VELEEPEDAR
IMLSRAVECC PTSVELWLAL ARLETYENAR KVLNKARENI PTDRHIWITA AKLEEANGNT
QMVEKIIDRA ITSLRANGVE INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK
HTWMEDADSC VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFGKNHGTR ESLEALLQRA
VAHCPKAEVL WLMGAKSKWL TGDVPAARSI LALAFQANPN SEEIWLAAVK LESENDEYER
ARRLLAKARS SAPTARVFMK SVKLEWVQDN IRAAQDLCEE ALRHYEDFPK LWMMKGQIEE
QKEMMEKARE AYNQGLKKCP HSTPLWLLLS RLEEKIGQLT RTRAILEKSR LKNPKNPGLW
LESVRLEYRA GLKNIANTLM AKALQECPNS GILWSEAIFL EARPQRRTKS VDALKKCEHD
PHVLLAVAKL FWSQRKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EERQEEVRKR
CESAEPRHGE LWCAVSEDIA NWQKKIGDIL RLVAGRIKNT F
