ID   PRPF3_CHICK             Reviewed;         684 AA.
AC   Q5ZJ85;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=U4/U6 small nuclear ribonucleoprotein Prp3;
DE   AltName: Full=Pre-mRNA-splicing factor 3;
GN   Name=PRPF3; ORFNames=RCJMB04_20b24;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5
CC       tri-snRNP complex that is involved in spliceosome assembly, and as
CC       component of the precatalytic spliceosome (spliceosome B complex).
CC       {ECO:0000250|UniProtKB:O43395}.
CC   -!- SUBUNIT: Component of the precatalytic spliceosome (spliceosome B
CC       complex) (By similarity). Component of the U4/U6-U5 tri-snRNP complex,
CC       a building block of the precatalytic spliceosome (spliceosome B
CC       complex) (By similarity). The U4/U6-U5 tri-snRNP complex is composed of
CC       the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8,
CC       PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3,
CC       SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and
CC       USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By
CC       similarity). {ECO:0000250|UniProtKB:O43395}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43395}. Nucleus
CC       speckle {ECO:0000255|PROSITE-ProRule:PRU00627}.
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DR   EMBL; AJ720549; CAG32208.1; -; mRNA.
DR   RefSeq; NP_001026561.1; NM_001031390.1.
DR   AlphaFoldDB; Q5ZJ85; -.
DR   SMR; Q5ZJ85; -.
DR   STRING; 9031.ENSGALP00000039818; -.
DR   GeneID; 426667; -.
DR   KEGG; gga:426667; -.
DR   CTD; 9129; -.
DR   VEuPathDB; HostDB:geneid_426667; -.
DR   eggNOG; KOG2769; Eukaryota.
DR   InParanoid; Q5ZJ85; -.
DR   OrthoDB; 1322299at2759; -.
DR   PhylomeDB; Q5ZJ85; -.
DR   PRO; PR:Q5ZJ85; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; ISS:UniProtKB.
DR   InterPro; IPR013881; Pre-mRNA_splic_Prp3.
DR   InterPro; IPR027104; Prp3.
DR   InterPro; IPR010541; Prp3_C.
DR   InterPro; IPR002483; PWI_dom.
DR   InterPro; IPR036483; PWI_dom_sf.
DR   PANTHER; PTHR14212; PTHR14212; 1.
DR   Pfam; PF06544; DUF1115; 1.
DR   Pfam; PF08572; PRP3; 1.
DR   Pfam; PF01480; PWI; 1.
DR   SMART; SM00311; PWI; 1.
DR   SUPFAM; SSF101233; SSF101233; 1.
DR   PROSITE; PS51025; PWI; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome; Spliceosome.
FT   CHAIN           1..684
FT                   /note="U4/U6 small nuclear ribonucleoprotein Prp3"
FT                   /id="PRO_0000312364"
FT   DOMAIN          1..87
FT                   /note="PWI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00627"
FT   REGION          73..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          162..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   684 AA;  77386 MW;  7B2E11DA8887FE63 CRC64;
     MSLSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH LKPFLDDSTL
     RFVDKLFEAV EEGRSSRHSK SNSDRNRKRE LKDVFGDDSE VSKESSGVKK RRIPRFEEVE
     DEPEVIPGPP SESPGMLTKL QIKQMMEAAT RQIEERKKQL SFISPPTPQP KISSSSQSER
     LPIGNTVQPS QAATFMNDAI EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI
     APPKVELKDQ TKPTPLILDE QGRTVDATGK EIELTHRMPT LKANIRAVKR EQFKQQLKEK
     PSEDMESNTY FDLRVSITPA QRQKRTFKFH EKGKFEKIAQ RLRTKAQLKK LQAEISQAAR
     KTGIHTSTKL ALITPKKELK EGEIPEIEWW DSYIIPNGLD LKGGTSSKKD EYFGITNLVE
     HPAQLNPPVD SDTPVTLGVY LTKKEQKKLR RQTRREAQKE LQEKVRLGLM PPPEPKVRIS
     NLMRVLGTEA VQDPTKVEAH VRAQMAKRQK AHEEANAARK LTAEQRKAKK IKKLKEDVSQ
     GVHIAVYRVR NLSNPAKKFK IEANAGQLYL TGVVVLHKDV NVVVVEGGPK AQKKFKRLML
     HRIKWDEQTS NTKGEDDDES DEESVKKTNK CSLVWEGTAK DRSFGEMKFK QCPTENMARE
     HFKKHGAEHY WDLALSESVL ESTD