ID   PRPG2_RAT               Reviewed;         295 AA.
AC   P10165; Q07611;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Proline-rich proteoglycan 2;
DE   AltName: Full=Acidic proline-rich protein PRP18;
DE   Flags: Precursor;
GN   Name=Prpg2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND GLYCOSYLATION.
RC   STRAIN=Sprague-Dawley; TISSUE=Parotid gland;
RX   PubMed=8376404; DOI=10.1016/s0021-9258(20)80752-2;
RA   Castle A.M., Castle J.D.;
RT   "Novel secretory proline-rich proteoglycans from rat parotid. Cloning and
RT   characterization by expression in AtT-20 cells.";
RL   J. Biol. Chem. 268:20490-20496(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-23.
RC   TISSUE=Parotid gland;
RX   PubMed=3840480; DOI=10.1016/s0021-9258(17)38745-8;
RA   Clements S., Mehansho H., Carlson D.M.;
RT   "Novel multigene families encoding highly repetitive peptide sequences.
RT   Sequence analyses of rat and mouse proline-rich protein cDNAs.";
RL   J. Biol. Chem. 260:13471-13477(1985).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8376404}.
CC   -!- PTM: Contains glycosaminoglycans of chondroitin-sulfate and heparan
CC       types.
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DR   EMBL; L17318; AAA03074.1; -; mRNA.
DR   EMBL; M11899; AAA41956.1; -; mRNA.
DR   PIR; B48013; B48013.
DR   RefSeq; NP_742062.1; NM_172065.2.
DR   AlphaFoldDB; P10165; -.
DR   PaxDb; P10165; -.
DR   GeneID; 257651; -.
DR   KEGG; rno:257651; -.
DR   UCSC; RGD:628797; rat.
DR   CTD; 381832; -.
DR   RGD; 628797; Prpg2.
DR   PRO; PR:P10165; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026086; Pro-rich.
DR   PANTHER; PTHR23203; PTHR23203; 2.
DR   Pfam; PF15240; Pro-rich; 1.
DR   SMART; SM01412; Pro-rich; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..295
FT                   /note="Proline-rich proteoglycan 2"
FT                   /id="PRO_0000022132"
FT   REGION          16..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..78
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..277
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..295
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        17
FT                   /note="Q -> H (in Ref. 2; AAA41956)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   295 AA;  30026 MW;  EEA44BD8B38E1B9F CRC64;
     MLVVLLTAAL LVLSSAQGVD EEVVYEDSSQ QLELEQQSQG HGQHHPKPPP GGLPPRPPAS
     DENGDGDDND DGDDDGSGDD VNRPERPPQH GGNHHHPHHP PPAAGPQRPP QPGSPQGPPP
     PGGPQQRPPQ GPPPQGGPQR PPQPGSPQGP PPPGGPQQRP PQGPPPQGGP QRPPQPGSPQ
     GPPPPGGPQQ RAPQGPPPQG GPQRPPQPGS PQGPPPPGGP QQRPPQGPPP QGGPQRPPQP
     GSPQGPPPPG GPQQRPPQGP PPQGGPQRPP QPGNPQGPPQ QGGQQQSSFL WSFSA